Evidence map›Paper›PMID 42290766›Full record

ArticleTrends in medicine2026

National Tissue Freezing Protocol is Essential for Modern Cancer Care and Research.

Margaret Simonian

Abstract read
In one paragraph

Article in Trends in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Margaret SimonianDavid Geffen School of Medicine, University of California Los Angeles.

Funding

New Technologies for Real-Time MRI-Guided Robotic-Assisted Abdominal InterventionsR01EB031934 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LU, DAVID S, TSAO, TSU-CHIN TC · 2022 to 2025
$2.5M
NIBIB NIH HHS R01 EB031934
6 · The paper itself

Abstract

Modern cancer care and precision medicine increasingly rely on high quality human tissue yet tissue preservation practices in many healthcare systems remain outdated. Traditional formalin-fixed paraffin-embedded (FFPE) tissues while long established, is poorly suited to modern molecular and multi-omics technologies due to chemical degradation of DNA, RNA, and proteins. In contrast tissue freezing preserves molecular integrity and enables advanced proteomics, transcriptomics, genomics, and metabolomics analyses that are essential for accurate diagnosis, treatment selection, and biomedical research. To address these disparities, there is a compelling case for adopting a fixed nationally agreed tissue freezing protocol such a protocol should be implemented across all hospitals and aligned with consent, storage, and transport standards. Without a standardized protocol valuable tissue samples may become unsuitable for modern diagnostics ultimately constraining both patient care and scientific advancement.

Identifiers

PMID42290766
PMCPMC13262702

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.