ArticleFrontiers in pediatrics2026
Association between hematocrit and cranial MRI abnormalities in neonatal hyperbilirubinemia.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: In the context of neonates, the association between hematocrit (HCT) and cranial MRI abnormalities continues to be a topic of controversy. At present, the available evidence regarding the relationship between HCT and cranial MRI abnormalities is inadequate. Objective: This study aims to elucidate the relationship between HCT and cranial MRI abnormalities in neonatal hyperbilirubinemia (NHB). Methods: We conducted a retrospective cross-sectional study of 410 neonates with hyperbilirubinemia. Neonatal blood parameters, maternal prenatal data, and cranial MRI findings were extracted from the electronic medical record system. Logistic regression and smooth curve fitting were used to analyze the associations. Results: After adjusting for confounding factors, multivariate logistic regression analysis showed that each 1% increase in HCT is associated with a 6% increase in the risk of cranial MRI abnormalities. Further exploratory subgroup analyses based on sex, mode of delivery, and GDM revealed no significant interactions between these subgroups (all Conclusions: Among NHB, higher HCT was significantly associated with higher risk of incident cranial MRI abnormalities. These findings suggest that HCT may serve as a potential risk factor for cranial MRI abnormalities and could be a relevant biomarker.
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