ArticleFrontiers in pediatrics2026
Outcomes of critically ill pediatric patients after haploidentical stem cell transplantation.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Haploidentical peripheral blood hematopoietic stem cell transplantation (haploPBSCT) is increasingly performed for both malignant and nonmalignant diseases. This study evaluated the outcomes of critically ill patients after haploPBSCT who were admitted to the pediatric intensive care unit (PICU). Methods: This single-center, retrospective study included pediatric patients who underwent haploPBSCT ( Results: A total of 63 patients met the inclusion criteria. The 30-day and in-hospital mortality rates were 33.3% and 50.8%, respectively. The most common reason for PICU admission was respiratory complications. In multivariate logistic regression analysis, chronic graft-vs.-host-disease was independently associated with 30-day mortality [ Conclusion: Thirty-day and in-hospital mortality rates after haploPBSCT were comparable to those reported for allogenic PBSCT. Most critically ill pediatric patients required PICU admission for respiratory complications. Ventilator use independently predicted in-hospital mortality, underscoring the importance of early detection and prevention of respiratory failure following haploPBSCT.
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