Evidence map›Paper›PMID 42290658›Full record

ArticleGenes & diseases2026

ADAR1p110 promotes hepatocellular carcinoma metastasis via the miR-451a/TUBA1A axis.

Liangzhan Sun, Hui Yang, Pengchao Hu, Jingyi Zheng, Yuyang Du, Shasha Wu, Han Gao, Hao Luo, Yanchen Wang, Fenfen Wang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Liangzhan SunSchool of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China.
Hui YangDepartment of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong 518000, China.
Pengchao HuDepartment of Oncology, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, Hubei 441000, China.
Jingyi ZhengShenzhen Hospital, Southern Medical University, Shenzhen, Guangdong 518000, China.
Yuyang DuDepartment of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong 518000, China.
Shasha WuDepartment of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong 518000, China.
Han GaoDepartment of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong 518000, China.
Hao LuoDepartment of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong 518000, China.
Yanchen WangShenzhen Hospital, Southern Medical University, Shenzhen, Guangdong 518000, China.
Fenfen WangDepartment of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong 518000, China.
Jingsong YanDepartment of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong 518000, China.
Xin-Yuan GuanDepartment of Clinical Oncology, The University of Hong Kong, Hong Kong SAR 999077, China.
Yan LiShenzhen Hospital, Southern Medical University, Shenzhen, Guangdong 518000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ADAR1 is overexpressed in hepatocellular carcinoma (HCC) and has been linked to poor prognosis, metastasis, and recurrence; however, its precise functions and underlying mechanisms, particularly in the context of metastasis, remain inadequately elucidated. This study seeks to elucidate the functions and underlying mechanisms of the most abundantly expressed isoform of ADAR1, ADAR1p110, in the setting of HCC metastasis. In this study, hepatocyte-specific ADAR1p110 knock-in mice and engineered HCC cell lines were utilized to investigate the function of ADAR1p110

Indexed as

ADAR1p110Hepatocellular carcinomaMetastasismiR-451aTUBA1A

Identifiers

PMID42290658
PMCPMC13254589

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.