ArticleMicrobiology and immunology2026
Distinct Innate Immune Responses Following Inoculation With a Replicon mRNA COVID-19 Vaccine.
Article in Microbiology and immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Innate immune responses trigger the development of adaptive immune responses through the production of cytokines. In the present study, we compared the cytokine production in mice inoculated with a novel replicon mRNA COVID-19 vaccine. Biphasic and prolonged IFN-γ production was observed after the first dose, and sustained production was observed after the second dose, whereas conventional mRNA vaccines induced a peak of IFN-γ production only on Day 1 after both first and second inoculations. These findings may be associated with the self-replicating properties of the replicon mRNA vaccine following inoculation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.