Evidence map›Paper›PMID 42290531›Full record

ArticleJournal of agricultural and food chemistry2026

Genistein from Thai Fermented Soybean (Thua-nao) Attenuates Osteoarthritis Pathogenesis via Dual Inhibition of NF-κB and MAPK Signaling: Evidence from Ex Vivo, Computational, and In Vitro Models.

Benjawan Wudtiwai, Aitthiphon Chongchai, Pattaralawan Sittiju, Atitaya Wayupat, Hathaichanok Chuntakaruk, Teera Chewonarin, Jetsada Ruangsuriya, Prachya Kongtawelert, Thanyaluck Phitak, Peraphan Pothacharoen

Abstract read
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In one paragraph

Article in Journal of agricultural and food chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Benjawan WudtiwaiThailand Excellence Center for Tissue Engineering and Stem Cell, Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Aitthiphon ChongchaiDepartment of Clinical Chemistry, Faculty of Medical Technology, Mahidol University, Phutthamonthon, Nakhon Pathom 73170, Thailand.
Pattaralawan SittijuThailand Excellence Center for Tissue Engineering and Stem Cell, Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Atitaya WayupatThailand Excellence Center for Tissue Engineering and Stem Cell, Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Hathaichanok ChuntakarukCenter of Excellence in Computational Molecular Biology, Chulalongkorn University, Bangkok 10330, Thailand.
Teera ChewonarinDepartment of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Jetsada RuangsuriyaDepartment of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Prachya KongtawelertThailand Excellence Center for Tissue Engineering and Stem Cell, Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0000-0002-5963-2796
Thanyaluck PhitakThailand Excellence Center for Tissue Engineering and Stem Cell, Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Peraphan PothacharoenThailand Excellence Center for Tissue Engineering and Stem Cell, Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0000-0002-8560-553X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aglycone isoflavones derived from fermented soybeans demonstrate antioxidant, anticancer, antiobesity, and anti-inflammatory properties, with evidence suggesting protective effects against cartilage deterioration. However, precise mechanisms in chondrocytes remain unclear. This study screened extracts from Thai fermented soybean (Thua-nao) for chondroprotective effects using an

Indexed as

GenisteinGlycine maxMitogen-Activated Protein KinasesNF-kappa BOsteoarthritisPlant ExtractsAnimalsChondrocytesFermentationHumansInterleukin-1betaMAP Kinase Signaling SystemSwineThailandGenisteinInterleukin-1betaMitogen-Activated Protein KinasesNF-kappa BPlant Extractscartilage degradationgenisteinmatrix metalloproteinasesosteoarthritisThai fermented soybean

Identifiers

PMID42290531
PMCPMC13307359

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.