Evidence map›Paper›PMID 42290516›Full record

ReviewFuture medicinal chemistry2026

Urease inhibitors: current advances, therapeutic potentials, and clinical challenges.

Omer Habis Alzoubi, Almu'atasim Khamees, Mohammad Basil Alzu'bi, Sarah Feras Freihat, Aya Attar, Hanan Abo Sameed, Rawan Alzubi, Amen Ahed Alsamarah, Raghad Yousef Yassin, Khayry Al-Shami and 3 more

Abstract readReview
In one paragraph

Review in Future medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Omer Habis AlzoubiDepartment of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan.
Almu'atasim KhameesDepartment of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan.
Mohammad Basil Alzu'biDepartment of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan.
Sarah Feras FreihatDepartment of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan.
Aya AttarDepartment of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan.
Hanan Abo SameedDepartment of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan.
Rawan AlzubiDepartment of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan.
Amen Ahed AlsamarahDepartment of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan.
Raghad Yousef YassinFaculty of Pharmacy, Yarmouk University, Irbid, Jordan.
Khayry Al-ShamiDepartment of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan.
Bahaa Al-TradDepartment of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia.
Raed M Al-ZoubiSurgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha, Qatar.
Mazhar Salim Al ZoubiDepartment of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urease is a nickel-dependent metalloenzyme that catalyzes urea hydrolysis, generating ammonia and elevating local pH, a process implicated in the pathogenesis of

Indexed as

Enzyme InhibitorsUreaseAnimalsHelicobacter InfectionsHelicobacter pyloriHumansEnzyme InhibitorsUreaseacetohydroxamic acidHelicobacter pylorihepatic encephalopathystruvite kidney stonesUrease inhibitors

Identifiers

PMID42290516
PMCPMC13557569

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.