ArticleJournal of the Chinese Medical Association : JCMA2026
Clinical utility of preoperative lymphocyte-albumin-neutrophil ratio for prognostication in patients with oral cancer undergoing surgery.
Article in Journal of the Chinese Medical Association : JCMA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSystemic inflammation and nutritional status are key determinants of prognosis in oral squamous cell carcinoma (OSCC). The neutrophil-to-lymphocyte ratio and serum albumin in peripheral blood are established markers reflecting host immune response and nutritional condition, respectively. The lymphocyte-albumin-neutrophil ratio (LANR), a composite index integrating these parameters, has emerged as a potential prognostic biomarker in several cancers; however, its role in OSCC remains unclear. This study aimed to evaluate the prognostic value of preoperative LANR in OSCC.
methodsWe retrospectively analyzed OSCC patients who underwent radical surgery between 2007 and 2017, randomly dividing them into training and validation cohorts by a 2:1 ratio. LANR was calculated by multiplying the absolute lymphocyte count by the serum albumin level and dividing by the absolute neutrophil count. The primary outcomes were 5-year overall survival (OS) and disease-free survival (DFS). Survival-associated factors were identified through univariate and multivariate Cox regression analyses, serving as the foundation for constructing a predictive nomogram model.
resultsThis study included a total of 660 patients, with 440 assigned to the training cohort and 220 to the validation cohort. A LANR cutoff value of 18.7 effectively stratified patients into distinct prognostic groups, demonstrating significant differences in survival outcomes. A low LANR independently predicted worse OS (hazard ratio [HR]: 1.54, 95% CI: 1.04-2.28; p = 0.03) and DFS (HR: 1.54, 95% CI: 1.08-2.19; p = 0.017). The LANR-based nomogram demonstrated strong predictive performance, with concordance indices of 0.75 and 0.71 in the training and validation cohorts, respectively.
conclusionPreoperative LANR serves as an independent prognostic marker in patients with OSCC. Incorporating LANR into risk models may enhance patient stratification and guide treatment strategies.
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