Evidence map›Paper›PMID 42290188›Full record

ArticleFEBS letters2026

PDIA1 promotes androgen receptor activation and prostate cancer cell survival through enhancing HMMR stability.

Sishu Yu, Zijian Kuang, Ping Yao, Jianling Xie

Abstract read
In one paragraph

Article in FEBS letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sishu YuSchool of Biology and Biological Engineering, South China University of Technology, University Town, Guangzhou, China.ORCID https://orcid.org/0009-0007-3588-1900
Zijian KuangSchool of Biology and Biological Engineering, South China University of Technology, University Town, Guangzhou, China.ORCID https://orcid.org/0009-0000-1829-6354
Ping YaoSchool of Biology and Biological Engineering, South China University of Technology, University Town, Guangzhou, China.
Jianling XieSchool of Biology and Biological Engineering, South China University of Technology, University Town, Guangzhou, China.ORCID https://orcid.org/0000-0002-0588-8016

Funding

Australian NHMRC Ideas Grant 2047980 to JXForeign Expert Program of Guangdong ProvinceMasonic Charities Trust via the Freemasons Centre for Male Health & Wellbeing (to J.X.)South China University of Technology's Double First Class initiative fund (to J.X.)the Flinders Foundation (to J.X.)the Program for Guangdong Introducing Innovative and Entrepreneurial Teams 2019ZT08Y318 to J.X
6 · The paper itself

Abstract

To sustain rapid proliferation, cancer cells increase protein synthesis, intensifying reliance on protein disulfide isomerase A1 (PDIA1). It is largely unknown whether disulfide bond formation of PDIA1 substrates is driven by one or both CGHC motifs. Using active-site trapping mutants in prostate cancer cells combined with mass spectrometry, we identified 29 proteins uniquely bound to the C

Indexed as

Hyaluronan ReceptorsProcollagen-Proline DioxygenaseProstatic NeoplasmsProtein Disulfide-IsomerasesReceptors, AndrogenCell Line, TumorCell MovementCell ProliferationCell SurvivalHumansMaleProtein StabilityUbiquitinationAR protein, humanHyaluronan ReceptorsP4HB protein, humanProcollagen-Proline DioxygenaseProtein Disulfide-IsomerasesReceptors, Androgenandrogen receptorHMMRPDIA1prostate cancer

Identifiers

PMID42290188
PMCPMC13358421

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.