Evidence map›Paper›PMID 42290183›Full record

ArticleBiology open2026

SPSP-1 is a sperm protein required for C. elegans hermaphrodite sperm production and embryogenesis.

Darline Murat, Margaret Nagorski, Ji Kent Kwah, Shannon Pfeiffer, Nancy Duker, Frank Döring, Aimee Jaramillo-Lambert

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Darline MuratDepartment of Biological Sciences, University of Delaware, Newark, Delaware 19716, USA.
Margaret NagorskiDepartment of Biological Sciences, University of Delaware, Newark, Delaware 19716, USA.
Ji Kent KwahDepartment of Biological Sciences, University of Delaware, Newark, Delaware 19716, USA.
Shannon PfeifferDepartment of Biological Sciences, University of Delaware, Newark, Delaware 19716, USA.ORCID 0009-0009-4662-7144
Nancy DukerDepartment of Biological Sciences, University of Delaware, Newark, Delaware 19716, USA.
Frank DöringDepartment of Molecular Prevention, University of Kiel, 24106 Kiel, Germany.
Aimee Jaramillo-LambertDepartment of Biological Sciences, University of Delaware, Newark, Delaware 19716, USA.ORCID 0000-0001-7697-8580

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI Shawn W Polson · 2012 to 2026
$67.2M
Vascular Consequences of Duchenne Muscular DystrophyP20GM113125 · NIGMS · UNIVERSITY OF DELAWARE · PI LENNON, SHANNON L. · 2016 to 2025
$23.3M
Understanding synovial macrophage inflamm-aging within osteoarthritisP20GM139760 · NIGMS · UNIVERSITY OF DELAWARE · PI DAWN M ELLIOTT · 2021 to 2026
$19.1M
New roles for Topoisomerase II in meiosisR35GM142524 · NIGMS · UNIVERSITY OF DELAWARE · PI JARAMILLO-LAMBERT, AIMEE · 2021 to 2025
$2.0M
Spinning Disk Confocal and Single Molecule Localization MicroscopeS10OD030321 · OD · UNIVERSITY OF DELAWARE · PI CAPLAN, JEFFREY L · 2021 to 2021
$562k
NIGMSNIGMS NIH HHS P20 GM103446NIGMS NIH HHS P20 GM113125NIGMS NIH HHS P20 GM139760NIGMS NIH HHS R35 GM142524NIGMS NIH HHS R35GM142524NIH HHS S10 OD030321NIH-NIGMS P40 0D010440
6 · The paper itself

Abstract

Development requires the fusion of two gametes each with a haploid complement of DNA and the necessary components (RNA, proteins, organelles) needed for early cellular processes and divisions. The C. elegans paternal-effect embryonic lethal gene, spe-11, is one of the few known sperm components required for normal development. Sperm-provided SPE-11 forms a complex with the oocyte protein OOPS-1 at fertilization that mediates egg activation events. In this manuscript, we identified SPSP-1, a sperm protein that is associated with SPE-11. We found that SPSP-1 co-localizes with SPE-11 during spermatogenesis and in spermatids. SPSP-1 does not appear to play a role in egg activation like SPE-11. However, SPSP-1 is required to produce normal levels of hermaphrodite sperm and for wild-type levels of embryonic viability.

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsEmbryonic DevelopmentSpermatozoaAnimalsMaleSpermatogenesisSperm ProteinsCaenorhabditis elegans ProteinsSperm ProteinsC. elegansFertilizationSPE-11SpermSpermatogenesisSpermiogenesis

Identifiers

PMID42290183
PMCPMC13382835

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.