Evidence map›Paper›PMID 42290164›Full record

ArticleMolecular nutrition & food research2026

Association of Carbohydrate Consumption and Bloating in Individuals With Different FTO Genotypes.

Pegah Saamani, Mohammad Manizadeh, Zahra Mahmoudi, Yeganeh Shekari, Faezeh Tejareh, Masoomeh Alsadat Mirshafaei, Fatemeh Sadat Fahimzad, Mohammadtaghi Ghorbani Hesari, Atefeh Aminifard, Mona Zendehdel and 4 more

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Article in Molecular nutrition & food research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Pegah SaamaniNutrition and Food Security Research Center, Shahid Sadoughi University of Medical Science, Yazd, Iran.
Mohammad ManizadehFaculty of Literature and Humanities, Vali-e-Asr University of Rafsanjan, Rafsanjan, Iran.
Zahra MahmoudiStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Yeganeh ShekariDepartment of Exercise Physiology, Islamic Azad University, Tabriz, Iran.
Faezeh TejarehDepartment of Nutrition, SR.C., Islamic Azad University, Tehran, Iran.
Masoomeh Alsadat MirshafaeiTonekabon Mazandaran Branch, Islamic Azad University, Tehran, Iran.
Fatemeh Sadat FahimzadDepartment of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Mohammadtaghi Ghorbani HesariMashhad University of Medical Sciences, Mashhad, Iran.
Atefeh AminifardIslamic Azad University, Tehran Medical Branch, Tehran, Iran.
Mona ZendehdelSchool of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Fatemeh Sadat Hashemi JavaheriDepartment of Clinical Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Negar ZareDepartment of Community Nutrition, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Saeid DoaeiDepartment of Community Nutrition, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Maryam GholamalizadehUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.

Funding

Shahid Beheshti University of Medical Sciences 43015547
6 · The paper itself

Abstract

Emerging evidence suggests that genetic variations in the FTO gene may modulate individual responses to dietary carbohydrate intake, potentially influencing susceptibility to gastrointestinal symptoms such as bloating. This study investigated the association between carbohydrate intake and bloating across different FTO genotypes. In this case-control study, 229 women with bloating and 224 healthy women were included. Dietary intake was assessed using a validated semi-quantitative food frequency questionnaire consisting of 168 items. FTO rs9939609 polymorphism was genotyped using Tetra-ARMS PCR. Logistic regression models were used to examine associations, adjusting for potential confounders. Among TT genotype carriers of the FTO rs9939609 polymorphism, individuals with bloating had significantly higher body weight and greater maltose intake than controls. In multivariable analyses, maltose was positively associated with bloating in TT carriers (OR = 1.938, 95% CI: 1.079-3.480, p = 0.027), whereas galactose was positively associated with bloating in AT/AA carriers (OR = 1.152, 95% CI: 1.022-1.298, p = 0.029). The findings suggest that genotype-informed dietary strategies regarding carbohydrate intake may be useful for managing bloating and related gastrointestinal symptoms.

Indexed as

Alpha-Ketoglutarate-Dependent Dioxygenase FTODietary CarbohydratesAdultCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenotypeHumansMiddle AgedPolymorphism, Single NucleotideAlpha-Ketoglutarate-Dependent Dioxygenase FTODietary CarbohydratesFTO protein, humanbloatingcarbohydrate intakeFTO genegene polymorphism

Identifiers

PMID42290164
PMCPMC13359277

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