ArticleBrain and behavior2026
Identification of Shared Genetic Variants and Haplotypes Associated With Schizophrenia and Depression.
Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionDepression is highly prevalent among individuals with schizophrenia and significantly influences disease progression, treatment response, and risk of suicide. Despite its clinical relevance, the genetic underpinnings of depression comorbidity in schizophrenia remain poorly understood. This study aimed to identify shared genetic variants and haplotypic structures contributing to the susceptibility of both conditions.
methodsWe systematically screened the GWAS catalog to identify genome-wide significant variants shared between schizophrenia and depressive disorders. Linkage disequilibrium (LD) data from the 1000 Genomes Project were subsequently used to identify overlapping LD-associated variants, followed by haplotype reconstruction using Phase 3 genotyping data. Finally, functional analyses including brain expression quantitative trait loci (eQTL) mapping and protein-protein interaction (PPI) network analysis of genes associated with the identified variants were performed to explore their potential biological relevance.
resultsTwelve shared GWAS variants were identified (p < 5×10
conclusionThese findings highlight potential genetic markers that may contribute to the overlapping etiology of schizophrenia and depression. The identified haplotypic structures offer promising candidates for future diagnostic panels and provide a basis for further investigating of the genetic mechanisms underlying comorbidity in psychiatric disorders.
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