Evidence map›Paper›PMID 42289723›Full record

ArticleStem cell research & therapy2026

Gli1⁺ cell aggregates promote type H vessel formation and orchestrate bone defect regeneration.

Chao Ma, Yu-Ru Gao, Hao Wang, Bing-Dong Sui, Shan-Shan Huang, Yi Zhang, Lu Liu, Xiao-Hui Zhang, Shu-Juan Xing, Yuan-Yuan Li and 7 more

Abstract read
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In one paragraph

Article in Stem cell research & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Chao Ma *State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an, 710032, Shaanxi, China.
Yu-Ru Gao *State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an, 710032, Shaanxi, China.
Hao Wang *State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an, 710032, Shaanxi, China.
Bing-Dong SuiState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an, 710032, Shaanxi, China.
Shan-Shan HuangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an, 710032, Shaanxi, China.
Yi ZhangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Medical Rehabilitation, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, China.
Lu LiuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an, 710032, Shaanxi, China.
Xiao-Hui ZhangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an, 710032, Shaanxi, China.
Shu-Juan XingDepartment of Basic Medical Sciences, School of Medicine, Xi'an Peihua University, Xi'an, 710125, China.
Yuan-Yuan LiState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an, 710032, Shaanxi, China.
Yi-Han XiaoState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an, 710032, Shaanxi, China.
Ya-Nan ZhengThe Second Department of Surgery, Jiuquan Satellite Launch Center Hospital, Jiuquan, 732750, Gansu, China.
Li-Heng RenDepartment of Stomatology, Jiuquan Satellite Launch Center Hospital, Jiuquan, 732750, Gansu, China.
Yan JinState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an, 710032, Shaanxi, China. yanjin@fmmu.edu.cn.
Chen-Xi ZhengState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an, 710032, Shaanxi, China. chenxizheng@fmmu.edu.cn.
Hao-Kun XuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an, 710032, Shaanxi, China. xuhaokun@fmmu.edu.cn.
Ji ChenState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an, 710032, Shaanxi, China. jim117cj@sohu.com.

Funding

National Natural Science Foundation of China 82301028National Natural Science Foundation of China 82371020National Natural Science Foundation of China 82401201Partner Laboratory Cooperation and Exchange Program Project of Fourth Military Medical University 2024HB014Project of State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration 2024MS04the China Postdoctoral Science Foundation BX20230485
6 · The paper itself

Abstract

backgroundRapid and stable regeneration of bone defects remains a pressing clinical challenge. We previously fabricated stem cell aggregates (CA) by mimicking developmental condensation and demonstrated their efficacy in promoting bone defect repair. Endogenous Gli1

methodsSingle-cell RNA sequencing was performed to characterize differential gene expression profiles between Gli1

resultsSingle-cell RNA sequencing revealed that, compared with Gli1

conclusionsThis study not only addresses a critical knowledge gap in Gli1

Indexed as

Bone RegenerationNeovascularization, PhysiologicZinc Finger Protein GLI1AnimalsCell AggregationCore Binding Factor Alpha 1 SubunitMesenchymal Stem CellsMiceMice, TransgenicOsteogenesisCore Binding Factor Alpha 1 SubunitGli1 protein, mouseZinc Finger Protein GLI1BoneCell aggregatesGli1+ cellRegenerationSkeletal stromal/progenitor cellsType H vessels

Identifiers

PMID42289723
PMCPMC13501827

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.