Evidence map›Paper›PMID 42289719›Full record

ArticleJournal of nanobiotechnology2026

A self-amplifying responsive nanoplatform for dual inhibition of fibroblast-like synoviocytes in rheumatoid arthritis: coupled regulation of cell cycle arrest and apoptosis.

Huifang Hao, Juan Li, Jian Zhang, Lujie Yu, Mingxin Zhao, Shutong Wu, Xiaorui Song, Weiwei Kang, Weiwei Zhang, Ruiping Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Huifang Hao *Laboratory of Molecular Imaging, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People's Hospital), Taiyuan, 030000, China.
Juan Li *Laboratory of Molecular Imaging, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People's Hospital), Taiyuan, 030000, China.
Jian Zhang *Laboratory of Molecular Imaging, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People's Hospital), Taiyuan, 030000, China.
Lujie YuLaboratory of Molecular Imaging, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People's Hospital), Taiyuan, 030000, China.
Mingxin ZhaoLaboratory of Molecular Imaging, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People's Hospital), Taiyuan, 030000, China.
Shutong WuLaboratory of Molecular Imaging, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People's Hospital), Taiyuan, 030000, China.
Xiaorui SongLaboratory of Molecular Imaging, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People's Hospital), Taiyuan, 030000, China.
Weiwei KangLaboratory of Molecular Imaging, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People's Hospital), Taiyuan, 030000, China.
Weiwei ZhangTongji Shanxi Hospital, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China. zhangweiwei1@sxbqeh.com.cn.
Ruiping ZhangLaboratory of Molecular Imaging, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People's Hospital), Taiyuan, 030000, China. zrp_7142@sxmu.edu.cn.
Ziliang ZhengLaboratory of Molecular Imaging, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People's Hospital), Taiyuan, 030000, China. zzlsxty@sxmu.edu.cn.

Funding

Central Guiding Local Science and Technology Development Fund Projects YDZJSX20231A054National Key R&D Program of China 2023YFC3402800
6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease that features by the overproliferation of fibroblast-like synoviocytes (FLSs). Rapid proliferation and defective apoptosis of FLSs drive the pathogenesis of RA. However, it lacks effective treatment due to monotherapy strategy, adverse effects of drugs, the heterogeneity of FLSs and so on. Herein, a self-amplifying pH-responsive nanoplatform (Mn/Si-Abe@BSA) is developed to induce cell cycle arrest and apoptosis for RA treatment. By loading abemaciclib (Abe) in the manganese-doped mesoporous silica nanoparticles (Mn-MSNs) and modifying with bovine serum albumin (BSA), the multifunctional nanoplatform is successfully fabricated with carbonic anhydrase (CA)-mimicking activity. The nanoplatform can effectively accumulate in the inflammed joints, after which the nanoplatform is in response to the mild acidic microenvironment to release Mn

Indexed as

ApoptosisArthritis, RheumatoidCell Cycle CheckpointsNanoparticlesSynoviocytesAnimalsFibroblastsHumansHydrogen-Ion ConcentrationManganeseSerum Albumin, BovineSilicon DioxideManganeseSerum Albumin, BovineSilicon DioxideCell cycle arrest and apoptosisDual inhibitionFibroblast-like synoviocytesRheumatoid arthritisSelf-amplifying nanoplatform

Identifiers

PMID42289719
PMCPMC13501646

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.