ArticleVeterinary research2026
Mechanisms by which SIRT2 modulates alveolar macrophage immunoreactivity to intervene in Actinobacillus pleuropneumoniae infection in piglets under cold stimulation.
Article in Veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Actinobacillus pleuropneumoniae - today's perspective on advances and challenges (2017- 2026).BMC veterinary research · 2026Review
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Authors and funding
12 authors.
Funding
Abstract
Actinobacillus pleuropneumoniae (APP) is a porcine respiratory pathogen that causes significant economic losses to the global swine industry. APP-induced piglet respiratory disease complex (PRDC) is highly prevalent in winter and triggers an intense inflammatory response in the lungs at disease onset, accompanied by severe infiltration of porcine alveolar macrophages (PAMs). The magnitude of the PAM-mediated immune response following APP infection is a key factor influencing the regression of respiratory disease. However, it remains unclear whether cold stimulation exacerbates this response. In this study, we found that cold stimulation exacerbated APP-induced lung injury and enhanced macrophage activation. Metabolomics and transcriptomics analyses revealed that immune cells underwent metabolic reprogramming in response to energy mobilisation after APP infection, thereby interfering with lung immune function. In addition, we identified silent information regulator 2 (SIRT2) as a key regulator of PAM activation and demonstrated at the molecular level that SIRT2 mediates the immune response to PAMs following APP infection by regulating the acetylation modification of NF-κB p65. In conclusion, our results elucidate the role of SIRT2 in regulating the immune response to PAMs in piglets infected with APP under low-temperature conditions. These findings may provide potential intervention targets and effective control pathways to address the overactivity of immune cells induced by environmental stress and reduce the high incidence of winter respiratory disease in piglets.
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