Evidence map›Paper›PMID 42289638›Full record

ArticleAnnals of surgical oncology2026

Longitudinal Symptom Recovery After Pancreatectomy: A Prospective Patient-Reported Outcomes Study using MDASI.

Koichi Tomita, Alexandra M Adams, Maho Takayama, Cong Pan, Shu-En Shen, Xuemei Wang, Xin Shelley Wang, Loretta A Williams, Elsa M Arvide, Connie To and 8 more

Abstract read
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In one paragraph

Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Koichi TomitaDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Alexandra M AdamsDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Maho TakayamaDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Cong PanDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Shu-En ShenDepartment of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Xuemei WangDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Xin Shelley WangDepartment of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Loretta A WilliamsDepartment of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Elsa M ArvideDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Connie ToDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Adriana GamboaDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jessica E MaxwellDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Rebecca A SnyderDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Michael P KimDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Ching-Wei D TzengDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jeffrey E LeeDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Matthew H G KatzDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Naruhiko IkomaDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. nikoma@mdanderson.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDetailed longitudinal data on symptom recovery after pancreatectomy and determinants of delayed recovery remain limited. This study prospectively characterized symptom trajectories and defined symptom-based recovery using patient-reported outcomes.

methodsThe study included 185 patients who underwent pancreatectomy between October 2020 and September 2025 (pancreatoduodenectomy [n = 106], distal pancreatectomy [n = 79]). Of the 185 patients, 121 (65%) underwent a robotic approach. The MD Anderson Symptom Inventory (MDASI) was completed preoperatively at seven postoperative time points through postoperative month (POM) 6. The top five symptoms and top three interference items were identified using mean postoperative day 3 scores. Composite symptom and interference scores were defined as the mean scores of those top items for each. Recovery was defined when both composite scores achieved ≤ 3 of 10 points. Cumulative recovery rates were compared by surgery type and approach, and cluster analysis was performed to identify patients with delayed recovery and contributing factors.

resultsThe top symptoms were pain, fatigue, sleep disturbance, drowsiness, and bloating, and the top interference items were general activity, working, and walking. Symptom recovery followed three phases: acute improvement (POD 3 to 14), a plateau (POD 14 to POM 1), and persistent recovery extending to POM 6. Fatigue persisted longest. Overall cumulative recovery rates were 68.1% on POM 1, 78.6% on POM 3, and 86.9% on POM 6. In cluster analysis, postoperative complications predicted delayed recovery, whereas surgery type and approach did not.

conclusionsEarly symptom burden improved over time, with changes varying by time point, but fatigue often persisted. Prevention of postoperative complications appears to be a key strategy for improving symptom recovery regardless of surgical approach.

Indexed as

Distal pancreatectomyMD Anderson Symptom Inventory (MDASI) surveyPancreatoduodenectomyPatient-reported outcomes (PROs)Postoperative symptom recovery

Identifiers

PMID42289638

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