Observational studyScientific reports2026
The prognostic value of different HPV infection statuses in cervical cancer.
Observational study in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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11 authors.
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Abstract
To compare oncological outcomes between HPV-positive and HPV-negative cervical cancer patients in a large Chinese multicenter cohort. This retrospective study included cervical squamous cell carcinoma, adenocarcinoma, and adenosquamous carcinoma. Propensity score matching (PSM, 2:1) was used to balance baseline characteristics. Kaplan-Meier method and Cox proportional hazards regression were applied to compare 5-year overall survival (OS) and disease-free survival (DFS). The proportional hazards assumption was tested. Multicenter heterogeneity was adjusted using center stratification. Missing data were managed by complete-case analysis and multiple imputation sensitivity analysis. A total of 11,215 eligible patients were included. Before PSM, the HPV-positive group showed significantly better 5-year OS (92.3% vs. 84.3%, P < 0.001) and DFS (88.0% vs. 79.6%, P < 0.001) than the HPV-negative group. Multivariable Cox analysis confirmed HPV negativity as an independent risk factor for OS (HR = 1.545, 95%CI 1.091-2.188, P = 0.014) and DFS (HR = 1.556, 95%CI 1.212-1.997, P < 0.001). After 2:1PSM, HPV-positive patients still had superior 5-year OS (88.4% vs. 84.3%, P = 0.004) and DFS (85.3% vs. 79.6%, P < 0.001). Among 7,998 patients who underwent radical surgery, similar results were observed before and after PSM. HPV-negative status is associated with inferior 5-year OS and DFS and serves as an independent adverse prognostic factor in cervical cancer, including patients treated with radical surgery.
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