Evidence map›Paper›PMID 42289535›Full record

SynthesisScientific reports2026

The effect of selective decontamination on antimicrobial resistance in intensive care patients: a systematic review and meta-analysis.

Frederique J C van Eerten, Joost D J Plate, Rolf H H Groenwold, Valentijn A Schweitzer, Jan A J W Kluytmans, Falco Hietbrink

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Frederique J C van EertenDepartment of Trauma Surgery, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, 3584 CX, Netherlands. F.J.C.vaneerten-3@umcutrecht.nl.ORCID http://orcid.org/0000-0002-3522-515X
Joost D J PlateDepartment of Surgery, Radboud University Medical Center, Nijmegen, Netherlands.ORCID http://orcid.org/0000-0003-4928-414X
Rolf H H GroenwoldDepartment of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands.ORCID http://orcid.org/0000-0001-9238-6999
Valentijn A SchweitzerDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0001-9640-7291
Jan A J W KluytmansDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0003-2665-6844
Falco HietbrinkDepartment of Trauma Surgery, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, 3584 CX, Netherlands.ORCID http://orcid.org/0000-0003-1462-6840

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Selective Digestive Decontamination (SDD) and Selective Oropharyngeal Decontamination (SOD) are applied to prevent infections amongst Intensive Care Unit (ICU) patients and have proven to reduce mortality and infection rates. However, concerns about the development of antimicrobial resistance persists, specifically after ICU discharge. The aim of this study was to assess the occurrence of antimicrobial resistance during ICU stay and after ICU discharge in patients who had received SDD, or SOD compared to control, explicitly at individual-patient level. A previous systematic review, which included studies on antimicrobial resistance after SDD or SOD published before 01-02-2012, was updated. All studies analyzing antimicrobial resistance during and after ICU stay, were included. All outcomes related to resistant pathogens, whether detected through colonization or infection, were included. Pooled odds ratios and 95% confidence intervals were calculated using the Mantel-Haenszel method with random effects. Analyses were done separately for SDD and SOD. Twenty-seven studies were included in the meta-analysis on the occurrence of antimicrobial resistance during ICU stay, yielding a protective association in patients receiving SDD; OR 0.73 (95%-CI 0.54;0.98, I

Indexed as

Anti-Bacterial AgentsCritical CareDecontaminationDrug Resistance, BacterialCross InfectionHumansIntensive Care UnitsOropharynxAnti-Bacterial AgentsAntimicrobial resistanceInfectionsIntensive care medicineSelective digestive decontamination

Identifiers

PMID42289535
PMCPMC13526849

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.