Evidence map›Paper›PMID 42289526›Full record

ArticleEuropean journal of pediatrics2026

Factors predicting the severity of gastrointestinal involvement in children with IgA vasculitis? A Turkish multicenter cohort study.

Nuran Belder, Büşra Acun, Didem Öztürk, Naile Kaya Yıldırım, Betül Öksel, Sıla Atamyıldız Uçar, Mehmet Orhan Erkan, Merve Kutlar Tanıdır, Ayça Bilge Sönmez, Tuba Kurt and 46 more

Abstract readMulticenter Study
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In one paragraph

Article in European journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

56 authors.

Nuran BelderDepartment of Pediatric Rheumatology, Faculty of Medicine, Gazi University, Ankara, Türkiye. nuran.belder@gmail.com.ORCID http://orcid.org/0000-0001-6058-5037
Büşra AcunDepartment of Pediatric Rheumatology, Faculty of Medicine, Gazi University, Ankara, Türkiye.
Didem ÖztürkDepartment of Pediatric Rheumatology, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Türkiye.
Naile Kaya YıldırımDepartment of Pediatric Rheumatology, Faculty of Medicine, Firat University, Elazig, Türkiye.
Betül ÖkselDepartment of Pediatric Rheumatology, Faculty of Medicine, Kocaeli University, Kocaeli, Türkiye.
Sıla Atamyıldız UçarDepartment of Pediatric Rheumatology, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Türkiye.
Mehmet Orhan ErkanDepartment of Pediatric Rheumatology, Faculty of Medicine, Hacettepe University, Ankara, Türkiye.
Merve Kutlar TanıdırDepartment of Pediatric Rheumatology, Faculty of Medicine, Gazi University, Ankara, Türkiye.
Ayça Bilge SönmezDepartment of Child Health and Diseases, Faculty of Medicine, Trakya University, Edirne, Türkiye.
Tuba KurtDepartment of Pediatric Rheumatology, University of Health Sciences, Bursa City Hospital, Bursa, Türkiye.
Hatice Dilara KarakaşDepartment of Pediatric Rheumatology, Diyarbakır Children's Hospital, Diyarbakır, Türkiye.
Selahaddin CevizbaşDepartment of Pediatric Rheumatology, Faculty of Medicine, Dokuz Eylul University, Izmir, Türkiye.
Mukaddes Kılıç SağlamDepartment of Child Health and Diseases, Faculty of Medicine, Duzce, Türkiye.
Saadet Nilay TığrakDepartment of Pediatric Rheumatology, Faculty of Medicine, Pamukkale University, Denizli, Türkiye.
Özge BabaDepartment of Pediatric Rheumatology, University of Health Sciences, Van Training and Research Hospital, Van, Türkiye.
Hakan KısaoğluDepartment of Pediatric Rheumatology, University of Health Sciences, Kayseri City Hospital, Kayseri, Türkiye.
Eda Nur DizmanDepartment of Pediatric Rheumatology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Türkiye.
Ferhat DemirDepartment of Pediatric Rheumatology, Acıbadem Ataşehir Hospital, Istanbul, Türkiye.
Mustafa ÇakanDepartment of Pediatric Rheumatology, University of Health Sciences, Zeynep Kamil Women and Children's Diseases Training and Research Hospital, Istanbul, Türkiye.
Ahmet GirgeçDepartment of Pediatric Rheumatology, Faculty of Medicine, Gaziantep University, Gaziantep, Türkiye.
Oya KökerDepartment of Pediatric Rheumatology, Faculty of Medicine, Marmara University, Istanbul, Türkiye.
Selçuk YükselDepartment of Pediatric Rheumatology, Canakkale Onsekiz Mart University, Canakkale, Türkiye.
Şeyda DoğantanDepartment of Pediatric Rheumatology, University of Health Sciences, Basaksehir Cam Ve Sakura City Hospital, Istanbul, Türkiye.
Batuhan KüçükaliDepartment of Pediatric Rheumatology, Faculty of Medicine, Gazi University, Ankara, Türkiye.
Nihal KaraçayırDepartment of Pediatric Rheumatology, Faculty of Medicine, Gazi University, Ankara, Türkiye.
Tuba GündoğduDepartment of Pediatric Rheumatology, University of Health Sciences, Ankara Etlik City Hospital, Ankara, Türkiye.
Hatice Adıgüzel DündarDepartment of Pediatric Rheumatology, Dr. Behcet Uz Pediatric Diseases and Surgery Training and Research Hospital, Izmir, Türkiye.
Tutku Doğan KuzucaDepartment of Pediatric Rheumatology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Türkiye.
Müge SezerDepartment of Pediatric Rheumatology, Ankara Training and Research Hospital, Ankara, Türkiye.
Seher ŞenerDepartment of Pediatric Rheumatology, Adana City Training and Research Hospital, Adana, Türkiye.
Gökçe SümerDepartment of Pediatric Rheumatology, Faculty of Medicine, Uludag University, Bursa, Türkiye.
Fatma Gül DemirkanDepartment of Pediatric Rheumatology, University of Health Sciences, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Türkiye.
Sema Nur TaşkınDepartment of Pediatric Rheumatology, Eskisehir City Hospital, Eskisehir, Türkiye.
Burcu Bozkaya YücelDepartment of Pediatric Rheumatology, Samsun Training and Research Hospital, Samsun, Türkiye.
Çisem YıldızDepartment of Pediatric Rheumatology, Faculty of Medicine, Gazi University, Ankara, Türkiye.ORCID http://orcid.org/0000-0002-6901-9944
Zahide Ekici TekinDepartment of Pediatric Rheumatology, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Türkiye.
Süleyman Ekrem AlbayrakDepartment of Pediatric Rheumatology, Faculty of Medicine, Firat University, Elazig, Türkiye.
Nihal ŞahinDepartment of Pediatric Rheumatology, Faculty of Medicine, Kocaeli University, Kocaeli, Türkiye.
Eray TunceDepartment of Pediatric Rheumatology, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Türkiye.
Erdal SağDepartment of Pediatric Rheumatology, Faculty of Medicine, Hacettepe University, Ankara, Türkiye.
Şeyma ErtemDepartment of Pediatric Rheumatology, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Türkiye.
Metin Kaya GürgözeDepartment of Pediatric Rheumatology, Faculty of Medicine, Firat University, Elazig, Türkiye.
Hafize Emine SönmezDepartment of Pediatric Rheumatology, Faculty of Medicine, Kocaeli University, Kocaeli, Türkiye.
Betül SözeriDepartment of Pediatric Rheumatology, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Türkiye.
Yelda BilginerDepartment of Pediatric Rheumatology, Faculty of Medicine, Hacettepe University, Ankara, Türkiye.
Emine Neşe ÖzkayınDepartment of Pediatric Nephrology, Faculty of Medicine, Trakya University, Edirne, Türkiye.
Erbil ÜnsalDepartment of Pediatric Rheumatology, Faculty of Medicine, Dokuz Eylul University, Izmir, Türkiye.
Müferet ErgüvenDepartment of Pediatric Rheumatology, Faculty of Medicine, Duzce University, Duzce, Türkiye.
Serkan TürkuçarDepartment of Pediatric Rheumatology, Faculty of Medicine, Pamukkale University, Denizli, Türkiye.
Kübra ÖztürkDepartment of Pediatric Rheumatology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Türkiye.
Ayşe BalatDepartment of Pediatric Rheumatology, Faculty of Medicine, Gaziantep University, Gaziantep, Türkiye.
Semanur ElmasDepartment of Pediatric Rheumatology, Samsun Training and Research Hospital, Samsun, Türkiye.
Selcan DemirDepartment of Pediatric Rheumatology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Türkiye.
Osman DönmezDepartment of Pediatric Rheumatology, Faculty of Medicine, Uludag University, Bursa, Türkiye.
Deniz Gezgin YıldırımDepartment of Pediatric Rheumatology, Faculty of Medicine, Gazi University, Ankara, Türkiye.
Sevcan A BakkaloğluDepartment of Pediatric Rheumatology, Faculty of Medicine, Gazi University, Ankara, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastrointestinal (GI) involvement of IgA vasculitis (IgAV) has various clinical presentations from isolated abdominal pain to severe gastrointestinal bleeding. The aim of this study is to determine the incidence of GI involvement in children with IgAV and identify the predictors of severe GI involvement. Medical records of IgAV patients with GI involvement from 30 centers in Türkiye between 2014 and 2024 were retrospectively reviewed. Patients were classified into two groups according to the severity of GI presentations: Group 1 consisted of mild GI involvement, while Group 2 had severe GI involvement. Severe GI involvement was observed in 476 (42%) out of 1131 patients. A significant postpandemic (after March 2020) increase in GI involvement was observed (p < 0.001). Abdominal pain as an initial symptom, vomiting, purpuric rash on upper extremities and trunk, and kidney involvement were more frequent in Group 2 than in Group 1 (all p < 0.01). Leukocytosis, neutrophilia, thrombocytosis, increased C-reactive protein (CRP) level and neutrophil-to-lymphocyte ratio (NLR), and decreased serum total protein and albumin levels were detected more frequently in Group 2 (all p < 0.01). In multivariate regression analysis, thrombocytosis, elevated NLR and CRP, hypoalbuminemia, abdominal pain preceding rash, vomiting, and upper extremity rash were associated with severe GI involvement (all p < 0.05). ROC analyses identified the following optimal cut-off values for predicting severe GI involvement: WBC > 12.90 10^3/µL, ANS > 7.81 10

Indexed as

Gastrointestinal DiseasesIgA VasculitisImmunoglobulin AVasculitisAbdominal PainAdolescentChildChild, PreschoolCohort StudiesFemaleHumansIncidenceMaleRetrospective StudiesRisk FactorsSeverity of Illness IndexImmunoglobulin AChildGastrointestinal involvementHypoalbuminemiaIgA vasculitis

Identifiers

PMID42289526

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