ARHI as a key regulator of EMT and metastasis in pancreatic cancer via the Notch-1 pathway.

Jingjing Liu, Yiqun Zhao, Ying Wang, Ying Shi, Qiang Zhi, Linlin Chen, Yuhao Ke, Jianlin Ren

Abstract read

In one paragraph

Article in Human genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jingjing Liu *Department of Gastroenterology, The National Key Clinical Specialty, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361005, Fujian Province, P. R. China. jingjingliu@xmu.edu.cn.

Yiqun Zhao *Department of Gastroenterology, The National Key Clinical Specialty, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361005, Fujian Province, P. R. China.

Ying Wang *Department of Gastroenterology, Zhongshan Hospital Xiamen Branch, Fudan University, Xiamen, 361015, Fujian Province, P. R. China.

Ying ShiDepartment of Gastroenterology, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, Guangdong, P. R. China.

Qiang ZhiDepartment of Gastroenterology, The National Key Clinical Specialty, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361005, Fujian Province, P. R. China.

Linlin ChenDepartment of Gastroenterology, The National Key Clinical Specialty, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361005, Fujian Province, P. R. China.

Yuhao KeDepartment of Gastroenterology, The National Key Clinical Specialty, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361005, Fujian Province, P. R. China.

Jianlin RenDepartment of Gastroenterology, The National Key Clinical Specialty, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361005, Fujian Province, P. R. China.

Funding

the National Natural Science Foundation of China 81772630the Natural Science Foundation of Fujian Province 2017J01377the Science and Technology Programs of the Tan Kah Kee Innovation Laboratory 2022050901Xiamen Young and Middle-Aged Key Talents Program for High-Quality Development 2024GZL-GG36

6 · The paper itself

Abstract

Pancreatic cancer cell metastasis is a major factor influencing prognosis. A Ras homologue member I (ARHI) was reported to regulate proliferation and apoptosis in pancreatic cancer; however, its role in invasion remains unclear. This study aimed to explore the role and related mechanisms of ARHI in pancreatic cancer metastasis. We revealed that in pancreatic cancer ARHI expression levels were consistent with aggressive cellular phenotypes, and that changes in endogenous ARHI protein expression led to corresponding alterations in epithelial-mesenchymal transition (EMT) markers. Furthermore, ARHI accelerated tumor invasion in pancreatic cancer cells and in a mouse hepatic metastasis model. Notably, this unusual promoting effect of ARHI on EMT and invasion in pancreatic cancer was primarily exerted through the Notch-1 signaling pathway. Collectively, our findings provide insight into the function and molecular mechanisms of ARHI in pancreatic cancer metastasis.

Indexed as

Epithelial-Mesenchymal TransitionPancreatic NeoplasmsReceptor, Notch1rho GTP-Binding ProteinsAnimalsCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansLiver NeoplasmsMiceNeoplasm InvasivenessNeoplasm MetastasisSignal TransductionNOTCH1 protein, humanReceptor, Notch1rho GTP-Binding Proteins

Identifiers

PMID42289496

DOI10.1007/s00439-026-02845-2

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.