ArticleScientific reports2026
A pilot study of the effect of norepinephrine dose on left ventricular-arterial coupling in patients with septic shock.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Left ventricular-arterial (V-A) coupling is a key determinant of cardiovascular performance, which integrates intrinsic myocardial contractility with ventricular afterload. Septic shock frequently disrupts this coupling, and norepinephrine (NE) may worsen it in some scenarios. In this study, we aimed to quantify the dose-response relationship between NE and V-A coupling and to test for interactions between NE and elapsed treatment time or cumulative infusion volume (IV) in patients with septic shock. In this single-center prospective cohort study, NE dose, hemodynamic indicators, IV, and pulse indicator continuous cardiac output (PiCCO) related parameters were collected every 3 h for 3-24 h and every 6 h for 24-48 h. The V-A coupling index was computed as the ratio of arterial elastance (Ea) to ventricular end-systolic elastance (Ees). Linear mixed effects models were used to estimate the effects of NE dose on Ea/Ees: Model 1 included NE dose, time, and interaction between NE and time (NE×Time); Model 2 added sex, age, body mass index, central venous pressure (CVP), IV, NE×Time, and NE×IV. The NE dose correlated positively with Ea/Ees. NE×Time was non-significant, indicating that the relationship between NE and Ea/Ees did not change over time. Each 1000 mL increase in IV decreased the Ea/Ees by 0.360; NE × IV showed no significance. High-dose NE exacerbated V-A decoupling without a time-dependent change. Cumulative IV modestly mitigated uncoupling, whereas the interaction between NE and IV was non-significant.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.