Evidence map›Paper›PMID 42289048›Full record

ReviewBriefings in bioinformatics2026

Decoding disease and therapy through multiomics integration and systems analysis.

Mano Joseph Mathew, Joyal Mathew, Ripsy Merrin Chacko, Jagadeesh Bayry, Jean-François Zagury

Abstract readReview
In one paragraph

Review in Briefings in bioinformatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mano Joseph MathewLaboratoire Génomique, Bioinformatique et Chimie Moléculaire, EA7528, Conservatoire National des Arts et Métiers, HESAM Université, 2 Rue Conté, 75003 Paris, Ile de France, France.ORCID 0000-0002-4930-6903
Joyal MathewAnhalt University of Applied Sciences, Bernburger Str. 55, 06366 Köthen (Anhalt), Germany.
Ripsy Merrin ChackoLaboratoire Génomique, Bioinformatique et Chimie Moléculaire, EA7528, Conservatoire National des Arts et Métiers, HESAM Université, 2 Rue Conté, 75003 Paris, Ile de France, France.
Jagadeesh BayryInstitut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, 15 Rue de l'École de Médecine, 75006 Paris, Ile de France, France.
Jean-François ZaguryLaboratoire Génomique, Bioinformatique et Chimie Moléculaire, EA7528, Conservatoire National des Arts et Métiers, HESAM Université, 2 Rue Conté, 75003 Paris, Ile de France, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Computational multiomics methods are based on machine learning methods, and are primarily used for classifying patients into subtypes, discovering novel biomarkers, drug repurposing, and advancing precision medicine. Advances in high-throughput technologies have enabled comprehensive profiling of multiple molecular layers, resulting in the emergence of multiomics approaches for a more accurate understanding of disease mechanisms, therapeutic targets, and biological heterogeneity. This review examines current applications of multiomics in oncology, ageing, and immune-mediated diseases, highlighting the strengths and challenges of integrative models in understanding disease mechanisms, identifying biomarkers, and guiding precision therapies. Integration strategies, from early to late fusion and horizontal to vertical frameworks, are also examined alongside recent advances in computational platforms and preprocessing techniques.

Indexed as

MultiomicsSystems BiologyBiomarkersGenomicsHumansMachine LearningNeoplasmsPrecision MedicineBiomarkersbiomarker discoverydata integrationfusion strategiesmultiomics

Identifiers

PMID42289048
PMCPMC13264839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.