ReviewJournal of nanobiotechnology2026
Recent progress of plant-derived extracellular vesicle-like nanoparticles integrated with biomaterials for skin repair.
Review in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Mechanistic Insights and Therapeutic Potential of Plant-Derived Exosome-Like Nanovesicles in Skin Tissue Regeneration.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The skin, serving as a crucial physical and immunological barrier, faces significant regenerative challenges after injury or dysfunction. Recently, plant-derived extracellular vesicle-like nanoparticles (PELNs) have emerged as a highly potent, cell-free therapeutic strategy for skin tissue engineering, offering rich bioactive components, low immunogenicity, and inherent biocompatibility. However, PELNs face limitations such as poor stability, weak targeting ability, and rapid clearance, hindering their clinical applications. The latest progress in integrating or engineering PELNs with functional biomaterial delivery systems provides a promising strategy to overcome these challenges. This review systematically explores the biological characteristics of PELNs, emphasizing the integration and engineering strategies with advanced biomaterials to enhance their therapeutic effects. Firstly, the synergistic mechanisms of PELN-biomaterial composites across diverse dermatological applications, including wound healing, skin photoaging, and inflammatory skin diseases were reviewed. Secondly, the corresponding mechanisms of immune microenvironment remodeling, angiogenesis, and the restoration of redox homeostasis were also summarized. Finally, the clinical translation and regulatory landscape with challenges and perspectives of PELN-biomaterial composites were analyzed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.