Evidence map›Paper›PMID 42288904›Full record

ArticleThrombosis journal2026

Perioperative management in a patient with congenital factor VII deficiency following mechanical valve replacement: a case report.

Xiaokang Luo, Xue Yang, Tucheng Sun, Xinjian Yan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thrombosis journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Xiaokang Luo *Department of Cardiovascular Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, No. 106 Zhongshan 2nd Road, Yuexiu District, Guangzhou, 510080, China.ORCID http://orcid.org/0000-0002-1343-4372
Xue Yang *Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai, China.
Tucheng SunDepartment of Cardiovascular Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, No. 106 Zhongshan 2nd Road, Yuexiu District, Guangzhou, 510080, China.
Xinjian YanDepartment of Cardiovascular Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, No. 106 Zhongshan 2nd Road, Yuexiu District, Guangzhou, 510080, China. yanxinjian@gdph.org.cn.

Funding

Xinjiang Key Laboratory of Artificial Intelligence Assisted Imaging Diagnosis Fund XJRGZN2024001
6 · The paper itself

Abstract

backgroundCongenital factor VII deficiency (CFVIID) is a rare hemorrhagic disorder which elevates perioperative bleeding risks. Mechanical prosthesis mandates lifelong anticoagulation, while international normalized ratio (INR) of CFVIID deviates significantly from the normal range which could not accurately reflect the real anticoagulation. Perioperative management for CFVIID patients undergoing mechanical valve replacement are highly challenging, with no clinical guidelines currently available. CASE PRESENTATION: We reported a 59-year-old CFVIID patient undergoing mechanical valve replacement. Perioperative recombinant activated factor VII (rFVIIa) replacement secured hemostasis. After postoperative cerebral thrombosis, anticoagulation of warfarin was initiated and guided by factor Ⅱ/Ⅹ activity (30-45%) rather than INR. No bleeding or recurrent thrombosis was observed.

conclusionsPerioperative rFVIIa replacement guarantees hemostatic safety for cardiac surgery. Lifelong warfarin anticoagulation is essential for CFVIID patient with mechanical prosthesis. Monitoring factor Ⅱ/Ⅹ activity instead of INR can balance bleeding and thrombosis risks for such cases.

Indexed as

Cerebral thrombosisCongenital factor VII deficiencyIndividualized hemostasisMechanical valve replacementPerioperative anticoagulation

Identifiers

PMID42288904
PMCPMC13501598

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.