ArticleJournal of biological engineering2026
Unravelling the metabolism of itaconate and related branched C5-dicarboxylates for CO
Article in Journal of biological engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Branched C5-dicarboxylates (C5-DCAs), such as itaconate, are high-value platform chemicals with diverse applications in the synthesis of bio-based polymers. In addition to their industrial relevance, itaconate has attracted attention as a key immunomodulatory metabolite. In this study, we demonstrated that Cupriavidus necator can grow on itaconate as its sole carbon source and identified key genes involved in its degradation through targeted deletions. These include multiple functional homologs of itaconate CoA-transferase, itaconyl-CoA hydratase, and (S)-citramalyl-CoA lyase, which collectively mediate itaconate catabolism. We also identified ItcR1, a LysR-type transcriptional regulator, as a key mediator of itaconate-responsive gene expression. Transcriptomic analysis revealed broader transcriptional responses to itaconate, methylsuccinate, and mesaconate, suggesting an expanded role of C5-DCA metabolism. Finally, by expressing a heterologous cis-aconitate decarboxylase, we achieved the autotrophic production of a C5-DCA mixture of methylsuccinate, citramalate, mesaconate, and itaconate from CO
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