Evidence map›Paper›PMID 42288859›Full record

ArticleBMC nutrition2026

Association between the lactate-to-albumin ratio and mortality in patients with protein-energy malnutrition: a retrospective cohort study.

Zhenpeng Xiao, Liangliang Zhang, Wei Qiu, Yang Jiang, Xinger Geng, Qian Yang, Anhua Tang, Youwei Lu, Huixia Wu, Lin Zhang

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Article in BMC nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Zhenpeng XiaoThe Critical Care Medicine, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230601, P.R. China.
Liangliang ZhangThe Critical Care Medicine, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230601, P.R. China.
Wei QiuThe Critical Care Medicine, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230601, P.R. China.
Yang JiangThe Critical Care Medicine, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230601, P.R. China.
Xinger GengThe Critical Care Medicine, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230601, P.R. China.
Qian YangThe Critical Care Medicine, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230601, P.R. China.
Anhua TangThe Critical Care Medicine, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230601, P.R. China.
Youwei LuThe Critical Care Medicine, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230601, P.R. China.
Huixia WuThe Critical Care Medicine, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230601, P.R. China.
Lin ZhangThe Critical Care Medicine, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230601, P.R. China. ch1990640014@fy.ahmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate the association between lactate-to-albumin ratio (LAR) levels and clinical outcomes in patients with protein-energy malnutrition (PEM).

methodsA retrospective analysis was conducted using the MIMIC-IV database. Patients with PEM were identified and stratified into four groups based on LAR quartiles. Cox regression models and restricted cubic spline (RCS) curves were employed to investigate the association between LAR and both 28-day ICU mortality and ICU mortality. Subgroup analyses were performed to compare the prognostic value of LAR across different populations.

resultsA total of 2,750 patients were included. Patients in the highest LAR quartile exhibited significantly higher 28-day ICU mortality and ICU mortality compared to those in the lowest quartile (both P < 0.001). After comprehensive adjustment for covariates, LAR remained significantly associated with 28-day ICU mortality (HR: 1.11, 95% CI: 1.01-1.22) and ICU mortality (HR: 1.19, 95% CI: 1.04-1.36) (both P < 0.05). Restricted cubic spline (RCS) curves indicated a non-linear relationship between LAR and both mortality outcomes. Sensitivity analyses further supported the robustness of the results.

conclusionLAR was independently associated with increased 28-day ICU and ICU mortality in patients with PEM, exhibiting a non-linear relationship. These findings highlight the potential of LAR as an indicator for risk stratification in the PEM population.

Indexed as

ICULactate-to-Albumin Ratio (LAR)MIMIC-IVMortalityProtein-energy malnutrition (PEM)

Identifiers

PMID42288859
PMCPMC13495274

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