Evidence map›Paper›PMID 42288854›Full record

ArticleGut pathogens2026

Prevalence of Helicobacter pylori infection and the associated demographic and histopathological characteristics in patients diagnosed with chronic gastritis in three histopathology laboratories in Uganda.

Okello Malcom Mark, Omega Phillip, Asiimwe Ivan, Byebei Eunice Chepkurui, Wanyenze Ester Fiona, Mawanda Anatoli, Boaz Mwesigwa, Musoke Sharrif, Lukande Robert, Bukirwa Phiona and 1 more

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Article in Gut pathogens, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Okello Malcom MarkDepartment of Pathology, Makerere University, P.O. Box 7072, Kampala, Uganda. okellomalcom@gmail.com.
Omega PhillipDepartment of Pathology, Makerere University, P.O. Box 7072, Kampala, Uganda.
Asiimwe IvanDepartment of Pathology, Makerere University, P.O. Box 7072, Kampala, Uganda.
Byebei Eunice ChepkuruiDepartment of Pathology, Makerere University, P.O. Box 7072, Kampala, Uganda.
Wanyenze Ester FionaDepartment of Pathology, Makerere University, P.O. Box 7072, Kampala, Uganda.
Mawanda AnatoliDepartment of Pathology, Uganda Cancer Institute, P.O. BOX 3935, Kampala, Uganda.
Boaz MwesigwaDepartment of Pathology, Mulago National Referral Hospital, P.O. Box 7051, Kampala, Uganda.
Musoke SharrifDepartment of Pathology, Mulago National Referral Hospital, P.O. Box 7051, Kampala, Uganda.
Lukande RobertDepartment of Pathology, Makerere University, P.O. Box 7072, Kampala, Uganda.
Bukirwa PhionaDepartment of Pathology, Makerere University, P.O. Box 7072, Kampala, Uganda.
Kalungi SamDepartment of Pathology, Makerere University, P.O. Box 7072, Kampala, Uganda.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHelicobacter pylori is the principal infectious driver of chronic gastritis, a precursor to several gastric lesions. Data on tissue-based prevalence and associated histopathology in Uganda remain limited. H. pylori affect over half the global population, leading to chronic gastritis and subsequent complications with increased risk of gastric cancer in about 1-3% of patients. This study investigated H. pylori prevalence, its demographic and histopathological associations among chronic gastritis patients in three histopathology laboratories in Uganda.

methodsA cross-sectional study analyzed 150 formalin-fixed paraffin-embedded tissue blocks of patients diagnosed with chronic gastritis between September 2018 to August 2021. The histopathology analysis was done using H&E and modified Giemsa stains. Data was analyzed with STATA version 17, determining prevalence through proportions, assessing associations using Chi-square tests and Fisher exact test. Significance was set at p ≤ 0.05 with 95% confidence intervals.

resultsThe study included 150 patients (male-to-female ratio 1.5:1; mean age 48 years, SD = 17, range 12-89). H. pylori prevalence was 29.3%. Significant associations were observed with chronic inflammation (p < 0.001), neutrophil activity (p < 0.001), glandular atrophy (p < 0.001) and intestinal metaplasia (p < 0.001).

conclusionH. pylori positivity was associated with more severe chronic inflammation and active neutrophilic infiltration, glandular atrophy and intestinal metaplasia.

Indexed as

Chronic gastritisHelicobacter pyloriHistopathologyPrevalenceUganda

Identifiers

PMID42288854
PMCPMC13281601

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