Evidence map›Paper›PMID 42288742›Full record

ArticleBMC plant biology2026

Genome-wide analysis of MYB and F3'5'H gene families in Vaccinium bracteatum provides insights into anthocyanin biosynthesis.

Lu Yang, Anqi Huang, Jinming Liu, Xiaojie Wang, Zhe Deng, Jianye Huang, Lixing Xiao, Rui Liu, Minghui Li, Dongsheng Du and 2 more

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Article in BMC plant biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Lu YangThe Anhui Provincial Key Laboratory of Biodiversity Conservation and Ecological Security in the Yangtze River Basin, College of Life Sciences, Anhui Normal University, Wuhu, 241000, Anhui, China. yanglu@ahnu.edu.cn.
Anqi HuangThe Anhui Provincial Key Laboratory of Biodiversity Conservation and Ecological Security in the Yangtze River Basin, College of Life Sciences, Anhui Normal University, Wuhu, 241000, Anhui, China.
Jinming LiuThe Anhui Provincial Key Laboratory of Biodiversity Conservation and Ecological Security in the Yangtze River Basin, College of Life Sciences, Anhui Normal University, Wuhu, 241000, Anhui, China.
Xiaojie WangThe Anhui Provincial Key Laboratory of Biodiversity Conservation and Ecological Security in the Yangtze River Basin, College of Life Sciences, Anhui Normal University, Wuhu, 241000, Anhui, China.
Zhe DengThe Anhui Provincial Key Laboratory of Biodiversity Conservation and Ecological Security in the Yangtze River Basin, College of Life Sciences, Anhui Normal University, Wuhu, 241000, Anhui, China.
Jianye HuangThe Anhui Provincial Key Laboratory of Biodiversity Conservation and Ecological Security in the Yangtze River Basin, College of Life Sciences, Anhui Normal University, Wuhu, 241000, Anhui, China.
Lixing XiaoThe Anhui Provincial Key Laboratory of Biodiversity Conservation and Ecological Security in the Yangtze River Basin, College of Life Sciences, Anhui Normal University, Wuhu, 241000, Anhui, China.
Rui LiuThe Anhui Provincial Key Laboratory of Biodiversity Conservation and Ecological Security in the Yangtze River Basin, College of Life Sciences, Anhui Normal University, Wuhu, 241000, Anhui, China.
Minghui LiThe Anhui Provincial Key Laboratory of Biodiversity Conservation and Ecological Security in the Yangtze River Basin, College of Life Sciences, Anhui Normal University, Wuhu, 241000, Anhui, China.
Dongsheng DuThe Anhui Provincial Key Laboratory of Biodiversity Conservation and Ecological Security in the Yangtze River Basin, College of Life Sciences, Anhui Normal University, Wuhu, 241000, Anhui, China.
Xuan GaoThe Anhui Provincial Key Laboratory of Biodiversity Conservation and Ecological Security in the Yangtze River Basin, College of Life Sciences, Anhui Normal University, Wuhu, 241000, Anhui, China.
Jiaxin XiaoThe Anhui Provincial Key Laboratory of Biodiversity Conservation and Ecological Security in the Yangtze River Basin, College of Life Sciences, Anhui Normal University, Wuhu, 241000, Anhui, China.

Funding

National Natural Science Foundation of China 32302166Provincial College Student Innovation and Entrepreneurship Training Program S202310370556
6 · The paper itself

Abstract

backgroundThe fruit of the oriental blueberry (Vaccinium bracteatum) is rich in anthocyanins, with the MYB transcription factor family and F3'5'H gene family playing key roles in anthocyanin biosynthesis. In this study, the MYB and F3'5'H gene families were investigated using bioinformatics analyses, including phylogenetic, motif, and gene structure analyses, while further functional characterization of VbF3'5'H7 was conducted.

resultsIn this study, a total of 156 VbMYB and nine VbF3'5'H members have been identified. Phylogenetic analysis confirmed the evolutionary relationships, and motif analysis revealed that both families contained conserved motifs, with greater diversity in VbMYBs. Moreover, purifying selection dominated VbMYBs and VbF3'5'Hs evolution. For gene location, VbMYBs were distributed randomly across all 12 chromosomes (Chr), whereas VbF3'5'Hs were localized exclusively to Chr4/6/10. The cis-acting elements prediction results showed that the promoters of most VbF3'5'Hs harbored MYB binding sites and ripening-related cis-elements such as ABRE and CGTCA. In addition, transcriptome data indicated that VbMYB and VbF3'5'H families may be involved in Vaccinium bracteatum fruit ripening. Transgenic tomato overexpressing VbF3'5'H7 showed elevated anthocyanins and photosynthetic pigments, with enhanced anti-inflammatory effects on RAW 264.7 cells.

conclusionsIn summary, this work provided insights into anthocyanin biosynthesis by genome-wide analysis of VbMYB and VbF3'5'H gene families, combined with the heterologous functional characterization of VbF3'5'H7 in transgenic tomato.

Indexed as

AnthocyaninsGenes, mybGenes, PlantPlant ProteinsTranscription FactorsGene Expression Regulation, PlantGenome-Wide Association StudyMultigene FamilyPhylogenyAnthocyaninsPlant ProteinsTranscription FactorsBlueberryFruit ripeningGene familyVaccinium bracteatum Thunb.VbF3'5'HVbMYB

Identifiers

PMID42288742
PMCPMC13491718

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