SynthesisBMC anesthesiology2026
Impact of intraoperative dexmedetomidine on postoperative outcomes in shoulder arthroscopy: a systematic review and meta-analysis.
Synthesis in BMC anesthesiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the effectiveness and safety of dexmedetomidine in adult patients undergoing shoulder arthroscopy.
methodsA systematic search was conducted in PubMed, Embase, and the Cochrane Library along with a manual search of reference lists from previous systematic reviews and meta-analyses. We applied random effects and fixed effects models for the analysis of outcomes, depending on the level of heterogeneity observed. We assessed the risk of bias using version 2 of the Cochrane Risk of Bias tool (RoB 2) and conducted sensitivity analyses to examine the robustness of our results. Additionally, evidence quality was rated using the GRADE system, with studies categorized as high quality (level I), moderate quality (level II or III), or low quality (level IV).
resultsEighteen randomized controlled trials involving 1,203 patients were included. Dexmedetomidine significantly reduced postoperative pain scores at 6 hours (SMD = -0.44, 95% CI -0.63 to -0.25) and 12 hours (SMD = -0.47, 95% CI -0.71 to -0.23) compared with those of the control groups. The incidence of PONV was also lower in the dexmedetomidine group (RR = 0.62, 95% CI 0.46-0.84). However, dexmedetomidine was associated with an increased risk of bradycardia (RR = 2.58, 95% CI 1.71-3.88) and hypotension (RR = 1.94, 95% CI 1.32-2.86). Although these findings should be interpreted with caution, as most studies reported these events without standardized definitions or severity grading.
conclusionDexmedetomidine appears to be effective at reducing postoperative pain and the incidence of nausea and vomiting following shoulder arthroscopy. Although the magnitude of pain reduction was modest, the effect was statistically significant and may still contribute to improved patient comfort and reduced opioid consumption when used as part of a multimodal analgesic regimen. Careful monitoring is recommended because of its potential hemodynamic effects, such as bradycardia and hypotension.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.