ArticleAnnals of biomedical engineering2026
Quantifying the Viscoelastic Properties of Pancreatic Tissue: A Comparative Study of Human, Porcine and Engineered Hydrogel.
Article in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Pancreatoduodenectomy (PD) is among the most complex abdominal procedures, with a leak from the pancreatic anastomosis (postoperative pancreatic fistula, POPF) continuing to be a major source of morbidity and mortality. The mechanical characteristics of the pancreas, particularly tissue texture, are closely linked to POPF risk, yet remain poorly defined, limiting the accuracy of currently available training models. This study sought to quantify the viscoelastic behaviour of human pancreatic tissue and to compare it with porcine pancreas and a commercially available synthetic substitute. Fresh and frozen human pancreatic samples, porcine lobes, and synthetic tissues underwent uniaxial compression ramp testing and dynamic mechanical analysis. Human pancreatic tissue was markedly 'stiffer' (mean Young's modulus 148.3 ± 117.0 kPa) compared with porcine (25.1 ± 17.1 kPa) and synthetic (34.5 ± 17.6 kPa) samples. Hard pancreas exhibited over twice the material stiffness of soft pancreas in both fresh (218.8 vs. 93.0 kPa, p < 0.001) and frozen (148.9 vs. 55.6 kPa, p = 0.002) states, whilst no significant variation was observed between different porcine lobes. Storage and loss modulus assessment demonstrated frequency-dependent differences, with synthetic models unable to reproduce the nonlinear viscoelastic profile of human tissue. These findings provide the first robust biomechanical benchmarks for pancreatic tissue and reveal the limitations of current phantoms. Integrating these data into advanced synthetic and computational models may improve surgical training, reduce the learning curve, and enhance patient outcomes after PD.
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