Cassipourol and β-sitosterol from Malva parviflora L.: a mechanistic study of dual anti-inflammatory action against COX/LOX and TNF-α/BCL-2.

Mohamed A Anwar, Rania A El Gedaily, Wael M Aboulthana, Ahmed Elshewy, Zeinab A Kandil, Shymaa I A Abdel-Dayem

Abstract read

In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohamed A AnwarPharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El Aini St., P.B. 11562, Cairo, Egypt. mohamed.anwar@pharma.cu.edu.eg.

Rania A El GedailyPharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El Aini St., P.B. 11562, Cairo, Egypt.

Wael M AboulthanaBiochemistry Department, Biotechnology Research Institute, National Research Centre, 33 El Bohouth St., P.O. 12622, Dokki, Giza, Egypt.

Ahmed ElshewyPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El Aini St., P.B. 11562, Cairo, Egypt.

Zeinab A KandilPharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El Aini St., P.B. 11562, Cairo, Egypt.

Shymaa I A Abdel-DayemPharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El Aini St., P.B. 11562, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although inflammation protects our bodies against harmful stimuli, uncontrolled inflammation drives serious chronic disorders. Malva parviflora L. (family Malvaceae) may represent a source for anti-inflammatory metabolites based on its potent anti-inflammatory activity. Its total ethanol extract demonstrated notable inhibition of cyclooxygenase-1/2 (COX-1/COX-2) and 5-lipoxygenase (5-LOX), with IC

Indexed as

Anti-Inflammatory AgentsCyclooxygenase InhibitorsProto-Oncogene Proteins c-bcl-2SitosterolsTumor Necrosis Factor-alphaArachidonate 5-LipoxygenaseCell Line, TumorCyclooxygenase 2HumansLipoxygenase InhibitorsMolecular Docking SimulationPlant ExtractsAnti-Inflammatory AgentsArachidonate 5-LipoxygenaseCyclooxygenase 2Cyclooxygenase Inhibitorsgamma-sitosterolLipoxygenase InhibitorsPlant ExtractsProto-Oncogene Proteins c-bcl-2SitosterolsTumor Necrosis Factor-alphaCassipourolCOX/LOXMalva parvifloraMolecular dockingNetwork pharmacologyβ-Sitosterol

Identifiers

PMID42288609

DOI10.1038/s41598-026-56631-1

PMCPMC13264612

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.