ArticleSleep medicine2026
Vitamin D supplement intake is associated with better cognition in persons with sleep disturbance and mild cognitive impairment.
Article in Sleep medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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5 authors.
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Abstract
introductionSleep disturbances affect nearly half of individuals with mild cognitive impairment (MCI), a population at elevated risk of progressing to Alzheimer's disease (AD). Vitamin D's role in cognitive outcomes, particularly among individuals with sleep disturbance and MCI, remains unclear. This study explored associations between cognitive function and vitamin D supplement intake in individuals with MCI and sleep disturbance-a high-risk group that may be more vulnerable to progression toward AD.
methodsThis cross-sectional study included 54 participants with diagnosed or suspected mild cognitive impairment (MCI) and disturbed sleep (as determined by validated sleep questionnaires). We administered the MoCA (Montreal Cognitive Assessment) to assess cognition. Disturbed sleep was defined using the Pittsburgh Sleep Quality Index (PSQI ≥ 5) or the Epworth Sleepiness Scale (ESS ≥ 10). Vitamin D supplement intake was assessed by self-reported questionnaire. A multiple linear regression model was utilized to examine the association between vitamin D supplement intake and cognitive impairment (MoCA score), controlling for covariates of age, sex, body mass index (BMI), vitamin D type, and education.
resultsParticipants had a mean age of 67.2±8.9, a mean BMI of 29.5±7.2 kg/m
conclusionTo our knowledge, this is the first study to evaluate the relationship between vitamin D supplemention and overall global cognition in individuals with both sleep disturbance and MCI. Our findings suggest that taking higher doses of daily vitamin D supplementation is associated with better overall cognitive performance in this population.
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