ArticleAngewandte Chemie (International ed. in English)2026
4-Formyl-N-Methylpyridinium-Mediated N-Terminal Cysteine Modification/Removal Facilitates One-Pot Multiplex Peptide Ligation.
Bingcheng Wei, Xinyao Wang, Farong Ye, Haozhan Wang, Gongyu Shi, Bing Liu, Ping Huang, Ping Wang
Abstract read
In one paragraphArticle in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
8 authors.
Bingcheng WeiCenter For Chemical Glycobiology, Shanghai Key Laboratory For Antibody-Drug Conjugates With Innovative Target, National Key Laboratory of Innovative Immunotherapy, Zhangjiang Institute for Advanced Study, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Xinyao WangThe First Affiliated Hospital of Harbin Medical University, School of Stomatology, Harbin Medical University, Harbin, China.
Farong YeShanghai Key Laboratory For Molecular Engineering of Chiral Drugs, State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, China.ORCID 0009-0004-0819-6623 Haozhan WangThe First Affiliated Hospital of Harbin Medical University, School of Stomatology, Harbin Medical University, Harbin, China.
Gongyu ShiCenter For Chemical Glycobiology, Shanghai Key Laboratory For Antibody-Drug Conjugates With Innovative Target, National Key Laboratory of Innovative Immunotherapy, Zhangjiang Institute for Advanced Study, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Bing LiuThe First Affiliated Hospital of Harbin Medical University, School of Stomatology, Harbin Medical University, Harbin, China.ORCID 0000-0002-0465-4947 Ping HuangThe First Affiliated Hospital of Harbin Medical University, School of Stomatology, Harbin Medical University, Harbin, China.ORCID 0000-0003-2363-0171 Ping WangCenter For Chemical Glycobiology, Shanghai Key Laboratory For Antibody-Drug Conjugates With Innovative Target, National Key Laboratory of Innovative Immunotherapy, Zhangjiang Institute for Advanced Study, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.ORCID 0000-0002-8640-1483 Funding
Interdisciplinary Program of Shanghai Jiao Tong University 20230102National Key Research and Development Program of China 2024YFA1306300National Natural Science Foundation of China 22225701National Natural Science Foundation of China 22477078Open Project of State Key Laboratory of Synergistic Chem-Bio Synthesis sklscbs202523Open Project of State Key Laboratory of Synergistic Chem-Bio Synthesis sklscbs202573Shanghai Key Laboratory for Antibody-Drug Conjugates with Innovative Target 24dz2261300Shanghai Municipal Science and Technology Major Project
6 · The paper itselfAbstract
The chemical synthesis of proteins with site-specific modifications remains a fundamental challenge in chemical biology. One-pot peptide ligation strategies have emerged as powerful tools to enhance synthetic efficiency, primarily relying on N-terminal cysteine (Cys) protection. However, current Cys deprotection conditions require various reagents or pH adjustments during the reaction, rendering downstream processing cumbersome. Here, a visible-light-mediated deprotection strategy using 2-(N-methylpyridinium-4-yl)-thiazolidine (4-NMP-Thz) as a novel N-terminal Cys-protecting group is reported. This reaction, catalyzed by [Ru(bpy)
Indexed as
CysteinePeptidesPyridinium CompoundsCatalysisHydrogen-Ion ConcentrationCysteinePeptidesPyridinium Compoundsdesulfurizationhydrazidephotocatalysisprotecting group
Identifiers
PMID42287676
PMCPMC13480665
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