Evidence map›Paper›PMID 42287657›Full record

ArticleAngewandte Chemie (International ed. in English)2026

A Molecular Trimming Strategy for Hypoxia-Tolerant Photosensitizers With Enhanced cGAS-STING Activation.

Dan Li, Yao Tu, Feng Chen, Jiayao Jiang, Tao Jin, Yongjie Zhu, Guoqing Wen, Sha Feng, Xintong Lin, Deliang Wang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Dan LiCollege of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, China.ORCID 0000-0003-1922-7689
Yao TuSchool of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, China.
Feng ChenCollege of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, China.
Jiayao JiangCollege of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, China.
Tao JinDepartment of Chemistry, University of Basel, Basel, Switzerland.
Yongjie ZhuCollege of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, China.
Guoqing WenCollege of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, China.
Sha FengSchool of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, China.
Xintong LinCollege of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, China.
Deliang WangDepartment of Materials Chemistry, Huzhou University, Huzhou, China.
Oliver S WengerDepartment of Chemistry, University of Basel, Basel, Switzerland.ORCID 0000-0002-0739-0553
Huaiyi HuangSchool of Pharmaceutical Science (Shenzhen), Shenzhen Campus of Sun Yat-Sen University, Shenzhen, China.
Bizhu ChuSchool of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, China.ORCID 0000-0002-3111-7653
Pingyu ZhangCollege of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, China.ORCID 0000-0002-2921-9490

Funding

Guangdong Basic and Applied Basic Research Foundation 2025A1515011507National Natural Science Foundation of China 22277153National Natural Science Foundation of China 22471295National Natural Science Foundation of China 22477080Natural Science Foundation of Guangdong Province 2023B1515020060Science and Technology Foundation of Shenzhen RCYX20221008092906021Shenzhen Medical Research Fund D2403005
6 · The paper itself

Abstract

The development of effective photosensitizers for photo-immunotherapy is highly desirable yet remains challenging, particularly given the prevailing reliance on π-conjugation extension in conventional molecular design. Herein, we propose a counterintuitive "π-bridge trimming" strategy to construct high-performance Ir(III) complexes photosensitizers. Unlike the conventional π-extension approach, the three-ring fused TTz-Ir outperforms its π-extended five-ring fused analog TBTz-Ir in multiple aspects, including molar absorptivity, solubility, photocatalytic activity, and photocytotoxicity. Mechanistic studies revealed that the superior performance of TTz-Ir stems from its longer triplet-state lifetime, more efficient charge separation, and transport favoring type I reactive oxygen species (ROS) generation. Upon light irradiation, TTz-Ir not only produces

Indexed as

Antineoplastic AgentsMembrane ProteinsNucleotidyltransferasesPhotosensitizing AgentsAnimalscGAS-STING Signaling PathwayCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseHumansIridiumReactive Oxygen SpeciesSTING ProteinAntineoplastic AgentscGAS protein, humanCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseIridiumMembrane ProteinsNucleotidyltransferasesPhotosensitizing AgentsReactive Oxygen SpeciesSTING1 protein, humanSTING ProteincGAS‐STING pathwayphotocatalystphoto‐immunotherapytriplet‐state lifetimeπ‐bridge trimming

Identifiers

PMID42287657
PMCPMC13480604

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.