Evidence map›Paper›PMID 42287508›Full record

ArticleIrish journal of medical science2026

Beyond immune recovery: Quality of life and psychosocial challenges in children with inborn errors of immunity after transplantation.

Sezin Aydemir, Ekin Nurhan, Isilay Turan, Necmiye Keser Ozturk, Betul Gemici Karaaslan, Zeynep Meric, Selami Ulas, Sevgi Bilgic Eltan, Haluk Cezmi Cokuğras, Elif Karakoç Aydıner and 8 more

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Article in Irish journal of medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

18 authors.

Sezin AydemirCerrahpasa Faculty of Medicine, Department of Pediatric Allergy and Immunology, Istanbul University-Cerrahpasa, Kocamustafapasa, Fatih, Istanbul, 34098, Türkiye.ORCID http://orcid.org/0000-0002-5876-2601
Ekin NurhanCerrahpasa Faculty of Medicine, Department of Pediatrics, Istanbul University-Cerrahpasa, Istanbul, Türkiye.ORCID http://orcid.org/0009-0000-7723-9165
Isilay TuranDepartment of Pediatric Allergy and Immunology, Basaksehir Cam and Sakura City Hospital, Istanbul, Türkiye.ORCID http://orcid.org/0000-0003-1297-1923
Necmiye Keser OzturkFaculty of Medicine, Department of Pediatrics, Division of Allergy and Immunology, Immune Deficiency Research and Application Center, Marmara University Hospital, Istanbul Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, The Isil Berat Barlan Center for Translational Medicine, Istanbul, Türkiye.ORCID http://orcid.org/0000-0003-2623-8626
Betul Gemici KaraaslanCerrahpasa Faculty of Medicine, Department of Pediatric Allergy and Immunology, Istanbul University-Cerrahpasa, Kocamustafapasa, Fatih, Istanbul, 34098, Türkiye.ORCID http://orcid.org/0000-0002-0303-7146
Zeynep MericCerrahpasa Faculty of Medicine, Department of Pediatric Allergy and Immunology, Istanbul University-Cerrahpasa, Kocamustafapasa, Fatih, Istanbul, 34098, Türkiye.ORCID http://orcid.org/0000-0003-1792-1570
Selami UlasDepartment of Pediatric Allergy and Immunology, Basaksehir Cam and Sakura City Hospital, Istanbul, Türkiye.ORCID http://orcid.org/0000-0003-1486-9690
Sevgi Bilgic EltanFaculty of Medicine, Department of Pediatrics, Division of Allergy and Immunology, Immune Deficiency Research and Application Center, Marmara University Hospital, Istanbul Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, The Isil Berat Barlan Center for Translational Medicine, Istanbul, Türkiye.ORCID http://orcid.org/0000-0003-0561-3343
Haluk Cezmi CokuğrasCerrahpasa Faculty of Medicine, Department of Pediatric Allergy and Immunology, Istanbul University-Cerrahpasa, Kocamustafapasa, Fatih, Istanbul, 34098, Türkiye.ORCID http://orcid.org/0000-0002-0086-3936
Elif Karakoç AydınerFaculty of Medicine, Department of Pediatrics, Division of Allergy and Immunology, Immune Deficiency Research and Application Center, Marmara University Hospital, Istanbul Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, The Isil Berat Barlan Center for Translational Medicine, Istanbul, Türkiye.ORCID http://orcid.org/0000-0003-4150-5200
Safa BarisFaculty of Medicine, Department of Pediatrics, Division of Allergy and Immunology, Immune Deficiency Research and Application Center, Marmara University Hospital, Istanbul Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, The Isil Berat Barlan Center for Translational Medicine, Istanbul, Türkiye.ORCID http://orcid.org/0000-0002-4730-9422
Ahmet OzenFaculty of Medicine, Department of Pediatrics, Division of Allergy and Immunology, Immune Deficiency Research and Application Center, Marmara University Hospital, Istanbul Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, The Isil Berat Barlan Center for Translational Medicine, Istanbul, Türkiye.ORCID http://orcid.org/0000-0002-9065-1901
Cigdem AydogmusDepartment of Pediatric Allergy and Immunology, Basaksehir Cam and Sakura City Hospital, Istanbul, Türkiye.ORCID http://orcid.org/0000-0002-6036-7694
Esra YucelCerrahpasa Faculty of Medicine, Department of Pediatric Allergy and Immunology, Istanbul University-Cerrahpasa, Kocamustafapasa, Fatih, Istanbul, 34098, Türkiye.ORCID http://orcid.org/0000-0003-3712-2522
Gizem DurcanCerrahpasa Faculty of Medicine, Department of Child and Adolescent Psychiatry, Istanbul University-Cerrahpasa, Istanbul, Türkiye.ORCID http://orcid.org/0000-0002-7863-4551
Mesut YavuzCerrahpasa Faculty of Medicine, Department of Child and Adolescent Psychiatry, Istanbul University-Cerrahpasa, Istanbul, Türkiye.ORCID http://orcid.org/0000-0002-6580-2093
Burak DogangunCerrahpasa Faculty of Medicine, Department of Child and Adolescent Psychiatry, Istanbul University-Cerrahpasa, Istanbul, Türkiye.ORCID http://orcid.org/0000-0002-0106-8256
Ayca KiykimCerrahpasa Faculty of Medicine, Department of Pediatric Allergy and Immunology, Istanbul University-Cerrahpasa, Kocamustafapasa, Fatih, Istanbul, 34098, Türkiye. ayca.kiykim@iuc.edu.tr.ORCID http://orcid.org/0000-0001-5821-3963

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHematopoietic stem cell transplantation (HSCT) provides definitive treatment for many inborn errors of immunity (IEI). Although most children achieve full immune reconstitution, long-term psychosocial and quality-of-life outcomes in medically stable survivors remain insufficiently understood.

methodsChildren aged 8-18 years with IEI who achieved complete immune recovery and had no chronic complications were included. Quality of life and psychological status were evaluated using the Pediatric Quality of Life Inventory (PedsQL-C) and the Revised Children's Anxiety and Depression Scale (RCADS). Healthy children matched for age, sex, and sociodemographic background served as controls.

resultsThirty-six patients and 41 controls participated. Children post-HSCT had significantly lower physical, psychosocial, and total quality-of-life scores (p = 0.022, 0.015, 0.006) and higher depression scores (p = 0.027). One-quarter of school-aged patients were not attending school, and one-third of families restricted exposure to crowded environments.

conclusionDespite immune recovery, children remain vulnerable to psychosocial challenges. These findings support incorporation of routine psychological assessment and family counseling into long-term post-HSCT follow‑up.

Indexed as

AnxietyChildrenHematopoietic stem cell transplantationInborn errors of immunityQuality of life

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.