Evidence map›Paper›PMID 42287492›Full record

ReviewActa neurologica Belgica2026

Neuro-visual pathway after mild traumatic brain injury: a systematic scoping review of symptoms, objective testing, and rehabilitation.

Ioannis Mavroudis, Foivos Petridis, Dimitrios Kazis, Ahmed Adel Mansour Kamar, Alin Ciobica, Diana Gheban, Catalin Morosan, Bogdan Gurzu, Otilia Novac, Bogdan Novac

Abstract readReview
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In one paragraph

Review in Acta neurologica Belgica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ioannis MavroudisLeeds Teaching Hospitals, NHS Trust, Leeds, UK.
Foivos PetridisThird Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Dimitrios KazisThird Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Ahmed Adel Mansour KamarGUPCO - Medical Department, Cairo office, Cairo, 11511, Egypt. ahmed81kamar@gmail.com.
Alin CiobicaDepartment of Biology, Faculty of Biology, "Alexandru Ioan Cuza" University of Iasi, Iasi, 700505, Romania.
Diana Gheban"Ioan Hăulică" Institute, "Apollonia" University of Iași, Iasi, 700511, Romania. diana.gheban@yahoo.com.
Catalin MorosanFaculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iasi, 700115, Romania.
Bogdan GurzuFaculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iasi, 700115, Romania.
Otilia NovacFaculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iasi, 700115, Romania.
Bogdan NovacFaculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iasi, 700115, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Visual complaints are common after mild traumatic brain injury (mTBI), yet the scope, assessment approaches, mechanisms, and rehabilitation strategies reported in the literature remain heterogeneous. To synthesize evidence on post-concussive visual symptoms, diagnostic/assessment approaches, treatment/rehabilitation strategies, and putative mechanisms. Relevant studies published between 1997 and 2025 were identified and screened; 57 studies reporting visual outcomes following mild traumatic brain injury were included. The literature comprised cohort and cross-sectional studies, randomized and non-randomized intervention studies, case series and case reports, as well as selected guidelines and reviews. Studies were tagged to five domains (Symptoms; Diagnosis/Assessment; Treatment/Rehabilitation; Pathophysiology/Mechanisms; Epidemiology). We performed narrative synthesis with quantitative tabulation and co-occurrence mapping (symptom-test; symptom-treatment). Frequencies of symptom types, assessment modalities, intervention categories, mechanistic signals, and their co-occurrences. Publications spanned 1997-2025, with 56.1% appearing in 2021-2025. Symptoms were reported in 49 studies, dominated by oculomotor disturbances (46.9%) and photophobia (36.7%); binocular anomalies were frequent (diplopia 18.4%; convergence insufficiency 16.3%; accommodative insufficiency 14.3%). Among 21 assessment papers, clinical tests used to assess binocular-vision metrics predominated (accommodation 57.1%; vergence 38.1%; NPC 19.0%), with selective device-based testing (VEP 19.0%; eye-tracking 14.3%; OCT 9.5%). Twenty-one treatment studies most often described vision/orthoptic therapy (47.6%) and vestibular-oculomotor rehabilitation (42.9%); prisms (19.0%) and tinted lenses (14.3%) were used in targeted subgroups. Mechanistic reports (n = 29) emphasized oculomotor control abnormalities (79.3%), with smaller contributions from VOR and VEP findings; structural correlates (DTI/OCT) were less common. Co-occurrence analyses showed dense links between oculomotor symptoms and accommodation/vergence/NPC testing, and between photophobia and spectral filters. Post-concussive visual sequelae are clinically coherent and largely reflect neuro-oculomotor dysfunction with frequent binocular anomalies and photosensitivity. High-yield assessment centers on vergence, accommodation, and NPC, optionally augmented by screening tools and selective device-based measures. The most consistent therapeutic signals favor vision/orthoptic and vestibular-oculomotor rehabilitation, with prisms and tinted lenses for select indications. Standardized outcomes and well-powered comparative trials are needed to strengthen recommendations. This review integrates symptoms, objective testing approaches, and rehabilitation outcomes across the neuro-visual sequelae of mTBI and provides a structured clinical mapping of symptom-test and symptom-treatment linkages.

Indexed as

AccommodationConcussionConvergence insufficiencyMild traumatic brain injuryOculomotorPhotophobiaVestibular-oculomotor rehabilitationVision therapyVisual symptoms

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.