Trial reportClinical oral investigations2026
Intraoral fluoride retention after using experimental toothpaste containing titanium tetrafluoride and chitosan.
Trial report in Clinical oral investigations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
Funding
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Abstract
objectivesThis clinical study evaluated the intraoral fluoride retention using Titanium tetrafluoride (TiF MATERIALS AND
methodsParticipants (n = 20) were randomly divided into double-blind and crossover phases according to the toothpastes: (1) TiF₄/Ch (1400 ppm F
resultsAfter 1 h, TiF₄/Ch toothpaste increased the mean fluoride levels in saliva (4.33 vs. 0.81 ppm for the placebo), biofilm fluid (0.25 vs. 0.18 ppm), solid biofilm (12.66 vs. 3.73 ppm), and total biofilm (22.14 vs. 3.19 ppm), similarly to TiF₄ and Elmex
conclusionsTiF₄/Ch toothpaste maintained fluoride retention in stimulated saliva and biofilm, similarly to the TiF CLINICAL RELEVANCE: TiF₄/Ch toothpaste showed prolonged fluoride retention in biofilm, comparable to the commercial toothpaste, supporting its potential as an alternative for maintaining intraoral fluoride reservoirs.
trial registrationThis study was registered at the Brazilian Registry of Clinical Trials (ReBEC) under number RBR-3f5c5hx.
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