ArticlePediatric radiology2026
Normative volumetric growth modeling of the whole fetal body, placenta, and amniotic fluid for three-dimensional T2-weighted magnetic resonance imaging.
Article in Pediatric radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- The placental maturation inflection point: an integrative biological framework for understanding early-onset versus late-onset preeclampsia.Frontiers in endocrinology · 2026Review
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Abstract
backgroundMagnetic resonance imaging (MRI)-based volumetry of the fetus, placenta, and amniotic fluid is clinically valuable but rarely used due to labor-intensive manual segmentation of motion-corrupted two-dimensional (2-D) stacks. Existing deep learning approaches are typically limited to single structures and 2-D data, while no robust automated solution exists for whole-uterus volumetry in reconstructed three-dimensional (3-D) MRI, and normative reference ranges are lacking.
objectiveTo develop an automated pipeline for whole-uterus volumetry in 3-D T2-weighted fetal MRI and derive normative growth models for fetal, placental, and amniotic fluid volumes. MATERIALS AND
methodsMotion-corrupted T2-weighted stacks (0.55-3-T field strength) were reconstructed into 3-D isotropic images using deformable slice-to-volume reconstruction, followed by automated segmentation with a 3-D U-Net. The method was applied to 357 normal-control datasets with confirmed term birth (16-41 weeks gestational age range) to derive quadratic normative growth curves. Performance and clinical utility were further evaluated on 43 independent datasets.
resultsSegmentation was highly accurate (Dice: fetus 0.997, placenta 0.995, amniotic fluid 0.998) with low volume errors (<1%) and minimal manual refinement required in <25% of cases. In the control cohort, fetal and placental volumes increased with gestational age (P<0.001), while amniotic fluid followed a quadratic trend. Longitudinal growth rates were 146.6 cc/week (fetus) and 38.8 cc/week (placenta). Preterm pregnancies showed significantly lower fetal and placental volumes (P<0.001) and reduced amniotic fluid (P<0.01).
conclusionThis work presents the first automated pipeline for simultaneous whole-uterus volumetry in 3-D fetal MRI and establishes normative growth models across gestation. The approach enables accurate, standardized volumetric assessment and provides a practical tool for detecting abnormal growth patterns in both normal and high-risk pregnancies.
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