ArticleAnalytical and bioanalytical chemistry2026
Molecularly imprinted polyvinylbenzoic acid based sensor for highly sensitive detection of acute lymphoblastic leukemia biomarker.
Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
According to data from the World Health Organization, acute lymphoblastic leukemia (ALL) constitutes approximately 80% of leukemia cases in pediatric populations and 20% in adults. The diagnosis of leukemia is predominantly established via hematological analyses and bone marrow biopsies; however, these diagnostic approaches present several inherent limitations and challenges. This study, a novel electrochemical sensor modified with a molecularly imprinted polymer (MIP) for the highly sensitive and selective detection of phosphoenolpyruvate (PEP), a clinically relevant biomarker, with the goal of facilitating early and straightforward diagnosis of acute lymphoblastic leukemia (ALL). A PEP-specific molecularly imprinted polymer (MIP) sensor was fabricated via a UV-induced photopolymerization process, employing p-vinylbenzoic acid (VBA) as the functional monomer and ethylene glycol dimethacrylate (EGDMA) as the cross-linking agent. The resulting polymer was subsequently immobilized onto a glassy carbon electrode (GCE). The developed sensor, that was PEP/VBA@MIP-GCE, demonstrated remarkable sensitivity, achieving a limit of detection (LOD) and limit of quantification (LOQ) of 2.24 × 10
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