Active electrode location does not influence weight gain after subthalamic nucleus deep brain stimulation surgery in Parkinson disease.

Amelia Heston, Asra Askari, Kara Wyant, Parag G Patil, Kelvin L Chou, Daniel Leventhal

Abstract read

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Article in Journal of neural transmission (Vienna, Austria : 1996), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Amelia HestonUniversity of Michigan Neurology, Ann Arbor, USA.

Asra AskariUniversity of Michigan Neurosurgery, Ann Arbor, USA.

Kara WyantUniversity of Michigan Neurology, Ann Arbor, USA.

Parag G PatilUniversity of Michigan Neurology, Ann Arbor, USA.

Kelvin L ChouUniversity of Michigan Neurology, Ann Arbor, USA.

Daniel LeventhalUniversity of Michigan Neurology, Ann Arbor, USA. dleventh@med.umich.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Weight change (WC) is a well-recognized and poorly understood side effect of deep brain stimulation (DBS). The aim of our study was to determine the relationship between active electrode location in the subthalamic nucleus (STN) and post-DBS WC. This was a single center retrospective study of 82 patients who underwent STN DBS. Two weeks after surgery, a head CT was obtained and co-registered to the patient's preoperative 3T MRI. The STN midpoint was identified, and the location of the active electrode was defined with respect to the STN midpoint in Talairach space. Least squares regression models were applied to evaluate the role of active electrode location on WC, as well as the relationships between WC and the explanatory variables sex, age, disease duration, change in levodopa equivalent dose (LED), change in MDS-UPDRS III scores, and change in dyskinesias before and after DBS. Active electrode contact location was not significantly associated with WC along any direction in either hemisphere. WC was significantly associated with change in dyskinesias (slope = -1.8 lbs/point, R

Indexed as

Deep brain stimulationParkinson diseaseSubthalamic nucleusWeight gain

Identifiers

PMID42287370

DOI10.1212/WNL.0b013e31825dcdc1

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