Evidence map›Paper›PMID 42287341›Full record

ArticleAging clinical and experimental research2026

Tissue-specific body composition changes and muscle performance decline: a 5-year prospective study.

Ling Wang, Yandong Liu, Wenshuang Zhang, Bo Hu, Kangkang Ma, Fengyun Zhou, Zitong Cheng, Qingyu Zhang, Xiaoguang Cheng, Yi Yuan and 2 more

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Article in Aging clinical and experimental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Ling WangDepartment of Radiology, Beijing Jishuitan Hospital, Capital Medical University, National Center for Orthopedics, Beijing, China.
Yandong LiuDepartment of Radiology, Beijing Jishuitan Hospital, Capital Medical University, National Center for Orthopedics, Beijing, China.
Wenshuang ZhangDepartment of Radiology, Beijing Jishuitan Hospital, Capital Medical University, National Center for Orthopedics, Beijing, China.
Bo HuDepartment of Radiology, Beijing Jishuitan Hospital, Capital Medical University, National Center for Orthopedics, Beijing, China.
Kangkang MaDepartment of Radiology, Beijing Jishuitan Hospital, Capital Medical University, National Center for Orthopedics, Beijing, China.
Fengyun ZhouDepartment of Radiology, Beijing Jishuitan Hospital, Capital Medical University, National Center for Orthopedics, Beijing, China.
Zitong ChengDepartment of Radiology, Beijing Jishuitan Hospital, Capital Medical University, National Center for Orthopedics, Beijing, China.
Qingyu ZhangDepartment of Radiology, Beijing Jishuitan Hospital, Capital Medical University, National Center for Orthopedics, Beijing, China.
Xiaoguang ChengDepartment of Radiology, Beijing Jishuitan Hospital, Capital Medical University, National Center for Orthopedics, Beijing, China.
Yi YuanDepartment of Radiology, Beijing Jishuitan Hospital, Capital Medical University, National Center for Orthopedics, Beijing, China. 1064604452@qq.com.
Giuseppe GuglielmiDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy. giuseppe.guglielmi@unifg.it.
Ling OeiDepartment of Internal Medicine, Erasmus MC, Rotterdam, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe change of muscle performance plays an important role in sarcopenia. Our objective was to examine longitudinal changes in body composition in older individuals in relation to changes in physical performance.

methods120 individuals were recruited from the neighborhood of the hospital. Computed tomography (CT) scans, handgrip strength (HGS) and the Timed Up and Go test (TUG) were obtained at baseline and follow-up after 5 years. Changes in muscle cross-sectional area and muscle density and adipose area were evaluated. Associations of changes in body composition with changes in HGS and TUG were tested in logistic regression models after adjusting for baseline age, height, weight and type 2 diabetes.

resultsAmong females, each decrease (per cm

conclusionsCT-based body composition changes, atrophy of thigh muscles in particular, are associated with loss of muscle strength and physical performance. ADVANCES IN KNOWLEDGE: Key findings include significant reductions in muscle size and density across multiple compartments (paraspinal, pelvic and thigh muscles), greater adipose tissue increase in females, and sex-specific associations between thigh muscle atrophy and declines in HGS and TUG performance. These results align with prior cross-sectional evidence of age-related sarcopenia but extend them by quantifying longitudinal changes and their functional consequences.

Indexed as

AgingBody CompositionMuscle, SkeletalSarcopeniaAgedAged, 80 and overFemaleHand StrengthHumansLongitudinal StudiesMaleMuscle StrengthProspective StudiesTomography, X-Ray ComputedAgeingBody compositionFollow-Up StudiesMuscle strengthPhysical performance

Identifiers

PMID42287341
PMCPMC13541913

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.