Evidence map›Paper›PMID 42287137›Full record

ReviewWomen's health (London, England)

Efficacy and safety of estrogen therapy for prevention of osteoporosis in postmenopausal women.

Frank Z Stanczyk, Sharon Winer, Intira Sriprasert, Adriana Wong, Donna Shoupe, Richard Paulson

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Women's health (London, England). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Frank Z StanczykDepartment of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-3607-121X
Sharon WinerDepartment of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Intira SriprasertDepartment of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0001-5367-762X
Adriana WongDepartment of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Donna ShoupeDepartment of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Richard PaulsonDepartment of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple randomized controlled trials and observational studies have demonstrated that estrogens reduce the risk of osteoporotic-related fractures, including hip and vertebral and nonvertebral fractures, in postmenopausal women. However, many clinicians have concerns about adverse effects of estrogen, particularly those related to breast cancer and cardiovascular disease (CVD). The US Food and Drug Administration (FDA) was concerned about the negative impact that their "black box warning" was having on the use of estrogen products. In November 2025, the FDA removed the "black box warning" on estrogen products, arguing that in 30 trials with 26,708 women participants, menopausal hormone therapy (HT) was not associated with increased cancer mortality. In fact, women who start HT before age 60 appear to have a decreased mortality risk. The present manuscript discusses the biologic effects of estrogens on bone, and its efficacy and safety. Although it is generally accepted that knowing the circulating estradiol (E

Indexed as

Estrogen Replacement TherapyEstrogensOsteoporosis, PostmenopausalBone DensityEstradiolFemaleHumansMiddle AgedOsteoporotic FracturesPostmenopauseEstradiolEstrogensbone lossbreast cancercardiovascular diseaseestrogen therapyfracturesmenopauseosteoporosis

Identifiers

PMID42287137
PMCPMC13264665

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.