Evidence map›Paper›PMID 42286978›Full record

ArticleCancer medicine2026

Radiotherapy and Cardiovascular Disease Survival Risk in Non-Small Cell Lung Cancer: A Population-Based Study From the Surveillance, Epidemiology, and End Results Database.

Chunhui Fan, Cuiping Hao, Li Liu, Mingyi Wen, Cunqi Li, Yian Geng, Wenxin Ren, Liping Zhang

Erratum issuedAbstract read
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In one paragraph

Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Chunhui FanDepartment of Oncology, Public Health Clinical Center Affiliated to Shandong University, Jinan, China.ORCID 0009-0004-6479-9584
Cuiping HaoDepartment of Respiratory and Critical Care Medicine, Qingzhou People's Hospital, Weifang, China.
Li LiuDepartment of Oncology, Public Health Clinical Center Affiliated to Shandong University, Jinan, China.
Mingyi WenDepartment of Oncology, Public Health Clinical Center Affiliated to Shandong University, Jinan, China.
Cunqi LiDepartment of Oncology, Public Health Clinical Center Affiliated to Shandong University, Jinan, China.
Yian GengDepartment of Traditional Chinese Medicine, Jinan Shizhong People's Hospital, Jinan, China.
Wenxin RenDepartment of Oncology, Public Health Clinical Center Affiliated to Shandong University, Jinan, China.
Liping ZhangMedical Care Department for Personnel, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt is well known that radiotherapy increases the cardiovascular risk of cancer patients, but there are few large-sample studies with cardiovasular-specific death as the endpoint in lung cancer patients.

methodsPatients aged ≥ 18 years diagnosed with non-small cell lung cancer were retrospectively enrolled from the Surveillance, Epidemiology, and End Results (SEER) database spanning the years 2004 to 2021. Multivariate Cox proportional hazards regression model was employed to assess prognostic factors influencing survival outcomes.

resultsA total of 89,569 patients met the eligibility criteria and were analyzed. Multivariate analysis did not find the effect of radiotherapy on CVD-specific survival in the population with non-small cell lung cancer (p = 0.58). Subgroup analysis was conducted on the queues before matching. Radiation therapy was found to be predictive of a higher risk of CVD-specific survival in regional patients (HR, 1.68, 95% CI 1.1-2.59) and in those with stage III (HR, 2.16, 95% CI 1.26-3.69). We explored the relationship between radiotherapy and CVD-specific survival at different follow-up times after diagnosis, and found that radiotherapy was a risk factor for CVD-specific survival in populations followed up for less than 2 years and 3-4 years.

conclusionOur analysis suggested that radiotherapy markedly amplified the risk of CVD-specific survival in regional patients and those categorized as stage III. It is notable that in the patient cohort with a follow-up period of less than 2 years, radiotherapy also became an independent risk factor for cardiovascular-related survival in this group of patients.

Indexed as

Carcinoma, Non-Small-Cell LungCardiovascular DiseasesLung NeoplasmsAdultAgedFemaleHumansMaleMiddle AgedPrognosisProportional Hazards ModelsRetrospective StudiesRisk FactorsSEER ProgramUnited Statescardiovascular diseasenon‐small cell lung cancerradiotherapythe surveillance, epidemiology, and end results (SEER)

Identifiers

PMID42286978
PMCPMC13263541

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.