Evidence map›Paper›PMID 42286933›Full record

Trial reportNeurogastroenterology and motility2026

Magnesium-Rich Mineral Water Improves Stool Consistency and Bowel Habits in Healthy Subjects: A Randomized Controlled Trial.

Hideki Yoneda, Toshihiko Tomita, Takayuki Kitano, Daisuke Morishita, Mio Kodani, Norio Nishii, Hiroo Sei, Hirotsugu Eda, Toshiyuki Sato, Mikio Kawai and 5 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Neurogastroenterology and motility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hideki YonedaDepartment of Gastroenterology, Hyogo Medical University School of Medicine, Nishinomiya, Hyogo, Japan.ORCID https://orcid.org/0009-0003-1785-8433
Toshihiko TomitaDepartment of Gastroenterology, Hyogo Medical University School of Medicine, Nishinomiya, Hyogo, Japan.
Takayuki KitanoDepartment of Gastroenterology, Hyogo Medical University School of Medicine, Nishinomiya, Hyogo, Japan.
Daisuke MorishitaDepartment of Gastroenterology, Hyogo Medical University School of Medicine, Nishinomiya, Hyogo, Japan.
Mio KodaniDepartment of Medical Health Science, Hyogo Medical University School of Medicine, Nishinomiya, Hyogo, Japan.
Norio NishiiDepartment of Medical Health Science, Hyogo Medical University School of Medicine, Nishinomiya, Hyogo, Japan.
Hiroo SeiDepartment of Gastroenterology, Hyogo Medical University School of Medicine, Nishinomiya, Hyogo, Japan.
Hirotsugu EdaDepartment of Gastroenterology, Hyogo Medical University School of Medicine, Nishinomiya, Hyogo, Japan.
Toshiyuki SatoDepartment of Gastroenterology, Hyogo Medical University School of Medicine, Nishinomiya, Hyogo, Japan.ORCID https://orcid.org/0000-0001-8307-2445
Mikio KawaiDepartment of Gastroenterology, Hyogo Medical University School of Medicine, Nishinomiya, Hyogo, Japan.
Yoko YokoyamaDepartment of Gastroenterology, Hyogo Medical University School of Medicine, Nishinomiya, Hyogo, Japan.
Masataka IgetaDepartment of Biostatistics, Hyogo Medical University School of Medicine, Nishinomiya, Hyogo, Japan.
Takuya OkugawaDepartment of Gastroenterology, Hyogo Medical University School of Medicine, Nishinomiya, Hyogo, Japan.
Hirokazu FukuiDepartment of Gastroenterology, Hyogo Medical University School of Medicine, Nishinomiya, Hyogo, Japan.
Shinichiro ShinzakiDepartment of Gastroenterology, Hyogo Medical University School of Medicine, Nishinomiya, Hyogo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMagnesium-rich mineral water influences stool consistency and bowel habits. However, randomized controlled trials directly comparing magnesium-rich mineral water with soft water using standardized bowel outcomes remain limited.

methodsThis single-center, randomized, parallel-group trial enrolled 40 healthy subjects who did not meet Rome IV criteria for chronic constipation or irritable bowel syndrome. After a 7-day observation period, participants consumed either soft water or magnesium-rich mineral water (1 L/day) for 14 days. The primary endpoint was change in weekly mean Bristol Stool Form Scale (BSFS) score from baseline to intervention week 2, analyzed using analysis of covariance. Secondary endpoints included spontaneous bowel movements (SBM; bowel movements without rescue medication), complete spontaneous bowel movements (CSBM; SBM with a sensation of complete evacuation), subjective global improvement, time to first SBM, and daily total fluid intake. KEY

resultsAll participants completed the trial. Compared with soft water, magnesium-rich mineral water significantly increased BSFS score at week 1 and week 2 (both p < 0.05). Weekly frequencies of SBM and CSBM were higher in the magnesium-rich mineral water group. Subjective improvement at week 2 was more frequent with magnesium-rich mineral water. Compared with the observation period, no difference in water intake was observed between the two groups. CONCLUSIONS AND INFERENCES: In healthy subjects, magnesium-rich mineral water was associated with stool softening and increased bowel movement frequency. No safety concerns were observed during the study period. These findings support further investigation of magnesium-rich mineral water as a strategy for modulating bowel habits.

Indexed as

ConstipationDefecationMagnesiumMineral WatersAdultFecesFemaleHealthy VolunteersHumansMaleMiddle AgedYoung AdultMagnesiumMineral Watersbowel movementsBristol stool form scalehealthy subjectsmagnesiummineral waterrandomized controlled trial

Identifiers

PMID42286933
PMCPMC13263547

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.