ArticlePest management science2026
Mutations M918T, M918L, and L1014F impair pyrethroid binding and alter gating of the Megalurothrips usitatus sodium channel.
Article in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMutations M918T/L and L1014F in the voltage-gated sodium channel (VGSC) are major causes of pyrethroid resistance in insects, but their functional effects in thrips remain unclear. We used Megalurothrips usitatus sodium channel (MuNa
resultsElectrophysiological analysis revealed that mutations shifted the voltage dependence of activation and inactivation. Notably, the L1014F mutation shifted the voltage dependence of activation by 8.32 mV in the depolarizing direction compared with wild-type MuNa
conclusionThis study provides direct evidence that M918T/L and L1014F mediate pyrethroid resistance in M. usitatus and other thrips species by altering VGSC gating properties and reducing pyrethroid sensitivity. These findings advance the functional understanding of kdr and super-kdr mutations in thrips and provide a critical basis for targeted resistance monitoring and the rational design of insecticide management strategies. © 2026 Society of Chemical Industry.
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