Evidence map›Paper›PMID 42286753›Full record

ArticleTrials2026

A comparative study of targeted end-tidal carbon dioxide versus standard management to guide resuscitation in emergency department cardiac arrest in Thailand: study protocol for a three-arm randomised controlled trial.

Winchana Srivilaithon, Chitlada Limjindaporn, Kumpol Kornthatchapong, Intanon Imsuwan, Kiattichai Daorattanachai, Nipon Diskumpon, Ittabud Dasanadeba, Yaowapha Siripakarn, Thosapol Ueamsaranworakul, Chatchanan Pornpanit and 2 more

Abstract readClinical Trial Protocol
In one paragraph

Article in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Winchana SrivilaithonDepartment of Emergency Medicine, Faculty of Medicine, Thammasat University, 99/209 Phahon Yothin Road, Klong Luang District, Pathum Thani, 12120, Thailand. winchanas@gmail.com.
Chitlada LimjindapornDepartment of Emergency Medicine, Faculty of Medicine, Thammasat University, 99/209 Phahon Yothin Road, Klong Luang District, Pathum Thani, 12120, Thailand.
Kumpol KornthatchapongDepartment of Emergency Medicine, Faculty of Medicine, Thammasat University, 99/209 Phahon Yothin Road, Klong Luang District, Pathum Thani, 12120, Thailand.
Intanon ImsuwanDepartment of Emergency Medicine, Faculty of Medicine, Thammasat University, 99/209 Phahon Yothin Road, Klong Luang District, Pathum Thani, 12120, Thailand.
Kiattichai DaorattanachaiDepartment of Emergency Medicine, Faculty of Medicine, Thammasat University, 99/209 Phahon Yothin Road, Klong Luang District, Pathum Thani, 12120, Thailand.
Nipon DiskumponDepartment of Emergency Medicine, Faculty of Medicine, Thammasat University, 99/209 Phahon Yothin Road, Klong Luang District, Pathum Thani, 12120, Thailand.
Ittabud DasanadebaDepartment of Emergency Medicine, Faculty of Medicine, Thammasat University, 99/209 Phahon Yothin Road, Klong Luang District, Pathum Thani, 12120, Thailand.
Yaowapha SiripakarnDepartment of Emergency Medicine, Faculty of Medicine, Thammasat University, 99/209 Phahon Yothin Road, Klong Luang District, Pathum Thani, 12120, Thailand.
Thosapol UeamsaranworakulDepartment of Emergency Medicine, Faculty of Medicine, Thammasat University, 99/209 Phahon Yothin Road, Klong Luang District, Pathum Thani, 12120, Thailand.
Chatchanan PornpanitDepartment of Emergency Medicine, Faculty of Medicine, Thammasat University, 99/209 Phahon Yothin Road, Klong Luang District, Pathum Thani, 12120, Thailand.
Nat ChatchairatanavejDepartment of Emergency Medicine, Faculty of Medicine, Thammasat University, 99/209 Phahon Yothin Road, Klong Luang District, Pathum Thani, 12120, Thailand.
Piyawat TivirachDepartment of Emergency Medicine, Faculty of Medicine, Thammasat University, 99/209 Phahon Yothin Road, Klong Luang District, Pathum Thani, 12120, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiac arrest managed in the emergency department (ED) is associated with suboptimal survival outcomes. End-tidal carbon dioxide (EtCO

methodsThis is a single-centre, three-arm, single-blind, superiority randomised controlled trial conducted in the ED of Thammasat University Hospital, Pathum Thani, Thailand. Eligible participants are patients with ED cardiac arrest, including out-of-hospital cardiac arrest patients receiving CPR in the ED and patients with first in-hospital cardiac arrest occurring in the ED. Exclusion criteria include age < 15 years, traumatic cardiac arrest, a do-not-attempt-resuscitation order, and signs of irreversible death. Post-randomisation exclusions include inability to obtain EtCO DISCUSSION: This trial will evaluate whether higher absolute or patient-specific EtCO

trial registrationThai Clinical Trials Registry (TCTR), TCTR20240619001, registered on 19 June 2024: https://www.thaiclinicaltrials.org/show/TCTR20240619001 .

Indexed as

CapnographyCarbon DioxideCardiopulmonary ResuscitationEmergency Service, HospitalHeart ArrestOut-of-Hospital Cardiac ArrestEquivalence Trials as TopicHumansReturn of Spontaneous CirculationSingle-Blind MethodThailandTidal VolumeTime FactorsTreatment OutcomeCarbon DioxideEmergency department cardiac arrestEnd-tidal carbon dioxideHigh-quality CPRImproving mortalityReducing mortalityROSCTargeted EtCO2

Identifiers

PMID42286753
PMCPMC13488267

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.