ArticleCancer cell international2026
Heterogeneous evolution of pancreatic cancer microvasculature revealed by longitudinal intravital imaging.
Article in Cancer cell international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with a 5-year survival rate below 10%. Despite strong pro-angiogenic signaling often activated in PDAC, clinical trials with anti-angiogenic therapies have consistently failed, underscoring the need to understand PDAC vasculature better. In this study, we established an intravital, longitudinal imaging platform using a pancreas window in an orthotopic Panc02-GFP murine PDAC model. After surgical inoculation of tumor cells and the window implantation, PDAC vasculature was labeled by intravenous injection of fluorophore-conjugated anti-CD31 antibody, and perfusion was tracked with fluorescent red blood cells (RBCs). Longitudinal imaging of same regions was performed with real-time intravital confocal microscopy. It revealed dynamic vascular remodeling during PDAC progression, including angiogenesis, vessel pruning, dilation, and regression. Real-time tracking of fluorescent RBCs further demonstrated heterogeneous perfusion: some vessels abruptly lost flow and collapsed, while neighboring vessels showed fluctuating or partially recovering perfusion. This approach enables repeated, long-term, cellular-level visualization of both vascular remodeling and perfusion dynamics in vivo. By uncovering the spatiotemporal dynamics of PDAC vasculature, our platform provides new insights into tumor development and offers a valuable tool to evaluate vessel-targeting therapies.
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