ReviewCell & bioscience2026
Molecular mechanisms and recent advances in cellular senescence.
Review in Cell & bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Senescence is an adaptive cellular mechanism initiated in response to diversified intrinsic and extrinsic stress stimuli, that lead to altered cellular and pathophysiological state. In this article we will review the comprehensive role of variable factors like oxidative stress, telomere attrition and oncogene activation in the initiation of senescence. Cells have a robust Redox system in place to counteract the effects of ROS/RNS mediated cell organelles and macromolecular damage to prevent senescence. The morphological, physiological and metabolic changes associated with progression of senescence and their molecular regulation at transcriptional and posttranscriptional levels has also been highlighted. The signaling pathways like p53/p21 and p16/pRB governing the senescence associated proliferative arrest and other complex cellular mechanisms that modulate the development and regulation of senescence associated secretory phenotype has been discussed in detail.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.