Evidence map›Paper›PMID 42286640›Full record

ArticleBMC veterinary research2026

Exploration of the relationship between laboratory stress parameters and leukocyte coping capacity in ponies exposed to repetitive handling during a research project.

Phebe De Heus, Jessica Maute, Nikolaus Huber, Alexander Tichy, Rupert Palme, Eike Steinmann, Asisa Volz, Jessika -M V Cavalleri, Dagmar S Trachsel

Abstract read
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In one paragraph

Article in BMC veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Phebe De HeusClinical Department for Small Animals and Horses, Clinical Centre for Equine Health and Research, University of Veterinary Medicine, Veterinärplatz 1, Vienna, 1210, Austria.
Jessica MauteClinical Department for Small Animals and Horses, Clinical Centre for Equine Health and Research, University of Veterinary Medicine, Veterinärplatz 1, Vienna, 1210, Austria.
Nikolaus HuberClinical Department for Farm Animals and Food System Science, Center for Food Science and Veterinary Public Health, University of Veterinary Medicine Vienna, Veterinärplatz 1, Vienna, 1210, Austria.
Alexander TichyDepartment of Biological Sciences and Pathobiology, Bioinformatics and Biostatistics Platform, University of Veterinary Medicine, Veterinärplatz 1, Vienna, 1210, Austria.
Rupert PalmeDepartment of Biological Sciences and Pathobiology, Unit of Physiology, Pathophysiology and Experimental Endocrinology, University of Veterinary Medicine, Veterinärplatz 1, Vienna, 1210, Austria.
Eike SteinmannDepartment of Molecular and Medical Virology, Ruhr University Bochum, Universitätsstrasse 150, 44801, Bochum, Germany.
Asisa VolzInstitute of Virology, University of Veterinary Medicine Hannover, Bünteweg 17, 30559, Hannover, Germany.
Jessika -M V CavalleriClinical Department for Small Animals and Horses, Clinical Centre for Equine Health and Research, University of Veterinary Medicine, Veterinärplatz 1, Vienna, 1210, Austria.
Dagmar S TrachselClinical Department for Small Animals and Horses, Clinical Centre for Equine Health and Research, University of Veterinary Medicine, Veterinärplatz 1, Vienna, 1210, Austria. dagmar.trachsel@vetmeduni.ac.at.

Funding

Austrian Science Fund I 4835-B
6 · The paper itself

Abstract

backgroundStress is an umbrella term indicating increased allostatic load with the potential to reach a pathological state of the organism. In this context, cortisol concentration and neutrophil granulocytes-to-lymphocyte ratio (NEU: LYM) are expected to increase. On the functional pathway, stress reduces the oxidative burst capacity of neutrophils and therefore, the leucocyte coping capacity (LCC) quantifying this oxygen radical generation of neutrophils. Therefore, we hypothesized that in ponies subjected to repetitive handling, LCC will decrease and will be negatively correlated with cortisol concentration and NEU: LYM ratio. Thus, LCC was measured over 90 min by a portable chemiluminometer in nine university owned ponies involved in a vaccination study that included handling and sampling over 42 days. The area under the curve for LCC (AUC

resultsAUC

conclusionWhile the slight decrease in LCC over time partially supported our hypothesis, we found no evidence of correlations among AUC

Indexed as

Handling, PsychologicalLeukocytesStress, PhysiologicalAnimalsArea Under CurveFemaleHorsesHydrocortisoneLymphocytesMaleNeutrophilsHydrocortisoneCortisolEquineNeutrophil granulocytes-to-lymphocyte ratioNeutrophil oxidative burstPMNLPolymorphonuclear cells

Identifiers

PMID42286640
PMCPMC13495423

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.