ArticleBMC neurology2026
Trends in both Alzheimer's disease and Diabetes mellitus related mortality among middle-aged and older adults in the United States, 1999 to 2023: a CDC WONDER database analysis.
Article in BMC neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo analyze the temporal trends of both Alzheimer's disease and Diabetes mellitus-related mortality in adults aged > 45years in the United States between 1999 and 2023, and to evaluate the changes in mortality patterns over time.
backgroundAlzheimer's Disease and Diabetes Mellitus are two different diseases that have diverse underlying pathophysiology, but they often coexist, having common pathways. There is a high prevalence of concurrence between these two conditions, yet their combined mortality trend is underexplored.
methodsWe utilize mortality data from the CDC Wide-Ranging Online Data for Epidemiologic Research (WONDER). Individuals aged > 45 were included who had both Alzheimer's disease (G30) and Diabetes mellitus(E10-14). Age-adjusted mortality rates (AAMRs) and crude mortality rates (CMRs) per 100,000 were calculated and were standardized to the 2000 U.S population. Joint point regression models were used to identify the temporal variations and to calculate Annual Percentage Change (APC) and Average Annual Percentage Change (AAPC) with 95% confidence intervals.
resultsOverall, a total of 224,082 deaths occurred in patients of both Alzheimer's disease and Diabetes mellitus, in the age group ≥ 45 years, from 1999 to 2023. There is an upward trajectory noted from 2.82 in 1999 to 4.42 in 2023, with the highest incidence between 2017 and 2020, followed by a decline. Mortality rose in both sexes, with a persistently higher rate in females. The mortality rise from 1999 to 2023 in middle-aged people (45-64 years), and there was a rise in the trend of around 41% among adults ≥ 65 years. White individuals show higher deaths (78.9%), yet higher AAMR is observed in Black and Hispanic populations, showing racial disparities. Regionally, the West shows the highest AAMR, while non-metropolitan areas show higher mortality than metropolitan areas.
conclusionThe trend of mortality in individuals with both Alzheimer's disease and Diabetes Mellitus has increased in the past two decades, but there is a sharp rise observed after 2020 that may show the impact of the COVID-19 pandemic. These findings emphasized public health strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.